RA Capital Management, LP |
21,853,958 |
8.54 |
-- |
3/31/23 |
Adage Capital Management, L.P. |
17,632,815 |
6.89 |
6,513,815 |
3/31/23 |
State Street Global Advisors (US) |
17,076,958 |
6.67 |
-431,155 |
3/31/23 |
Janus Henderson Investors |
16,450,081 |
6.43 |
13,302,505 |
3/31/23 |
BlackRock Institutional Trust Company, N.A. |
14,985,073 |
5.85 |
-130,047 |
3/31/23 |
The Vanguard Group, Inc. |
14,938,335 |
5.84 |
589,887 |
3/31/23 |
Wellington Management Company, LLP |
9,864,785 |
3.85 |
638,077 |
3/31/23 |
Redmile Group, LLC |
8,046,217 |
3.14 |
-486,600 |
3/31/23 |
Maverick Capital, Ltd. |
7,856,409 |
3.07 |
977,466 |
3/31/23 |
Two Sigma Investments, LP |
4,585,020 |
1.79 |
-671,225 |
3/31/23 |
Morgan Stanley & Co. LLC |
4,344,999 |
1.70 |
1,141,861 |
3/31/23 |
Geode Capital Management, L.L.C. |
4,039,396 |
1.58 |
200,306 |
3/31/23 |
Nuveen LLC |
3,193,514 |
1.25 |
1,905,334 |
3/31/23 |
Artisan Partners Limited Partnership |
3,181,379 |
1.24 |
3,181,379 |
3/31/23 |
Millennium Management LLC |
2,976,924 |
1.16 |
2,043,204 |
3/31/23 |
DWS Investments UK Limited |
2,942,799 |
1.15 |
8,735 |
3/31/23 |
Candriam Belgium S.A. |
2,389,296 |
0.93 |
-300,000 |
3/31/23 |
Jennison Associates LLC |
2,308,596 |
0.90 |
-6,831,763 |
3/31/23 |
Candriam Luxembourg S.A. |
2,282,557 |
0.89 |
-- |
4/30/23 |
Segall Bryant & Hamill, LLC |
2,243,746 |
0.88 |
-30,818 |
3/31/23 |
BofA Global Research (US) |
1,834,386 |
0.72 |
326,627 |
3/31/23 |
Northern Trust Investments, Inc. |
1,799,019 |
0.70 |
3,460 |
3/31/23 |
Goldman Sachs & Company, Inc. |
1,705,448 |
0.67 |
-231,652 |
3/31/23 |
Charles Schwab Investment Management, Inc. |
1,559,021 |
0.61 |
-2,563 |
3/31/23 |
BlackRock Financial Management, Inc. |
1,434,127 |
0.56 |
125,716 |
3/31/23 |
QVT Financial LP |
1,375,900 |
0.54 |
-- |
3/31/23 |
Rafferty Asset Management LLC |
1,367,970 |
0.53 |
-243 |
3/31/23 |
Pinnacle Associates Ltd. |
1,326,479 |
0.52 |
-7,079 |
3/31/23 |
Tang Capital Management, LLC |
1,274,853 |
0.50 |
-- |
3/31/23 |
Rhenman & Partners Asset Management AB |
1,250,000 |
0.49 |
-250,000 |
3/31/23 |
PanAgora Asset Management Inc. |
1,217,142 |
0.48 |
145,791 |
3/31/23 |
Dimensional Fund Advisors, L.P. |
1,191,797 |
0.47 |
-1,212,259 |
3/31/23 |
Putnam Investment Management, L.L.C. |
1,151,153 |
0.45 |
29,841 |
3/31/23 |
Fidelity Management & Research Company LLC |
1,132,374 |
0.44 |
2,051 |
3/31/23 |
Citi Investment Research (US) |
1,099,652 |
0.43 |
496,726 |
3/31/23 |
Sectoral Asset Management Inc. |
1,001,444 |
0.39 |
197,500 |
3/31/23 |
Citadel Advisors LLC |
975,058 |
0.38 |
948,435 |
3/31/23 |
Sofinnova Investments, Inc |
924,532 |
0.36 |
-761,622 |
3/31/23 |
Morgan Stanley Smith Barney LLC |
894,359 |
0.35 |
27,391 |
3/31/23 |
Granahan Investment Management, Inc. |
864,766 |
0.34 |
-1,321,192 |
3/31/23 |
Fisher Investments |
855,717 |
0.33 |
3,685 |
3/31/23 |
Banque Lombard Odier & Cie SA |
790,143 |
0.31 |
-146,358 |
3/31/23 |
Lombard Odier Asset Management (Europe) Ltd |
788,360 |
0.31 |
104,150 |
2/28/23 |
BlackRock Advisors (UK) Limited |
749,089 |
0.29 |
-- |
4/30/23 |
BlackRock Asset Management Ireland Limited |
716,469 |
0.28 |
9,721 |
3/31/23 |
J.P. Morgan Securities LLC |
693,266 |
0.27 |
690,521 |
3/31/23 |
Voya Investment Management LLC |
691,201 |
0.27 |
-36,982 |
3/31/23 |
Susquehanna International Group, LLP |
658,816 |
0.26 |
334,180 |
3/31/23 |
Medical Strategy GmbH |
622,173 |
0.24 |
82,817 |
1/31/23 |
BNY Mellon Asset Management |
602,365 |
0.24 |
353 |
3/31/23 |