Investors & Media

Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 307 925.24 92.09 203,249,488
Mutual Fund 247 214.55 18.71 41,047,849
Insider 9 4.21 0.40 885,636

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 120 85.45 8.60 18,985,724
Sellers 171 -177.87 17.59 -38,829,551
Net -92.41 8.99 -19,843,827

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 929.45 92.49 204,135,124
Top 10 Inst. 575.34 57.93 127,853,191
Top 20 Inst. 711.53 70.71 156,066,235
Top 50 Inst. 844.66 84.14 185,706,242

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 65 70.52 7.08 15,620,193
Aggressive Growth 3 2.18 0.22 483,304
Core Growth 51 42.60 4.27 9,416,336
Growth 11 25.75 2.59 5,720,553
Income 6 3.16 0.32 701,509
Income Value 3 3.14 0.32 698,029
Yield 3 0.02 -- 3,480
Index 32 269.35 27.05 59,709,287
Other 95 485.31 48.49 107,029,781
Broker Dealer 25 37.53 3.78 8,340,453
GARP 26 72.73 6.95 15,347,346
Hedge Fund 39 366.74 36.92 81,495,934
Specialty 4 3.17 0.32 705,260
VC Private Equity 1 5.13 0.52 1,140,788
Value 40 81.57 7.63 16,834,236
Core Value 31 70.95 6.56 14,483,792
Deep Value 9 10.62 1.06 2,350,444

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
RA Capital Management, LP 21,741,458 9.85 -- 6/30/22
State Street Global Advisors (US) 18,199,554 8.25 4,492,165 6/30/22
The Vanguard Group, Inc. 16,059,020 7.28 580,504 6/30/22
Deerfield Management Company, L.P. 15,020,490 6.81 240,900 6/30/22
BlackRock Institutional Trust Company, N.A. 14,959,232 6.78 464,766 6/30/22
Adage Capital Management, L.P. 11,586,193 5.25 -- 6/30/22
Wellington Management Company, LLP 10,717,085 4.86 -2,346,399 6/30/22
Redmile Group, LLC 9,141,045 4.14 -76,900 6/30/22
ClearBridge Investments, LLC 5,372,065 2.43 -130,778 6/30/22
Millennium Management LLC 5,057,049 2.29 1,557,032 6/30/22
Two Sigma Investments, LP 4,852,445 2.20 304,695 6/30/22
Morgan Stanley & Co. LLC 3,763,494 1.71 75,952 6/30/22
Geode Capital Management, L.L.C. 3,685,781 1.67 196,412 6/30/22
DWS Investments UK Limited 2,917,053 1.32 -14,723 6/30/22
Maverick Capital, Ltd. 2,766,474 1.25 2,766,474 6/30/22
Candriam Luxembourg S.A. 2,732,557 1.24 -- 8/31/22
Norges Bank Investment Management (NBIM) 1,934,900 0.88 1,934,900 12/31/21
Granahan Investment Management, Inc. 1,881,796 0.85 -75,923 6/30/22
Citadel Advisors LLC 1,850,041 0.84 1,112,373 6/30/22
Northern Trust Investments, Inc. 1,828,503 0.83 -57,721 6/30/22
Dimensional Fund Advisors, L.P. 1,611,076 0.73 1,611,076 6/30/22
Tang Capital Management, LLC 1,500,000 0.68 -- 6/30/22
Charles Schwab Investment Management, Inc. 1,464,219 0.66 -36,000 6/30/22
Renaissance Technologies LLC 1,448,740 0.66 -13,600 6/30/22
Pinnacle Associates Ltd. 1,390,532 0.63 -14,136 6/30/22
QVT Financial LP 1,375,900 0.62 -- 6/30/22
BlackRock Financial Management, Inc. 1,333,179 0.60 544,426 6/30/22
Rhenman & Partners Asset Management AB 1,200,000 0.54 -225,000 6/30/22
PanAgora Asset Management Inc. 1,161,213 0.53 -12,642 6/30/22
Sofinnova Investments, Inc 1,140,788 0.52 -287,381 6/30/22
Candriam Belgium S.A. 1,056,439 0.48 1,056,439 6/30/22
Banque Lombard Odier & Cie SA 1,004,626 0.46 -1,270,783 6/30/22
Fidelity Management & Research Company LLC 1,004,083 0.45 -1,562,939 6/30/22
D. E. Shaw & Co., L.P. 976,927 0.44 -274,750 6/30/22
Nuveen LLC 958,551 0.43 -1,231,506 6/30/22
Sectoral Asset Management Inc. 940,244 0.43 61,400 6/30/22
BofA Global Research (US) 888,491 0.40 66,301 6/30/22
Morgan Stanley Smith Barney LLC 877,672 0.40 13,709 6/30/22
Segall Bryant & Hamill, LLC 854,646 0.39 10,483 6/30/22
Citi Investment Research (US) 803,285 0.36 619,203 6/30/22
Rafferty Asset Management LLC 748,016 0.34 -104,868 6/30/22
PRIMECAP Management Company 728,327 0.33 -28,500 6/30/22
BlackRock Advisors (UK) Limited 720,679 0.33 7,968 9/30/22
FundLogic SAS 688,051 0.31 -- 6/30/22
Goldman Sachs & Company, Inc. 685,141 0.31 161,161 6/30/22
BlackRock Asset Management Ireland Limited 681,102 0.31 440,905 6/30/22
Wells Fargo Advisors 629,852 0.29 15,416 6/30/22
BlackRock Investment Management, LLC 625,899 0.28 2,653 6/30/22
Managed Account Advisors LLC 602,973 0.27 -35,269 6/30/22
Medical Strategy GmbH 539,356 0.24 -- 5/31/22

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