Investors & Media

Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 294 1,016.58 88.49 179,300,778
Mutual Fund 241 232.76 19.53 39,515,447
Insider 9 5.92 0.44 900,734

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 118 48.77 4.24 8,593,720
Sellers 153 -132.24 10.77 -21,819,140
Net -83.47 6.53 -13,225,420

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 1,022.50 88.94 180,201,512
Top 10 Inst. 655.79 57.08 115,660,351
Top 20 Inst. 813.37 70.80 143,451,574
Top 50 Inst. 936.24 81.52 165,176,609

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 64 58.67 5.11 10,351,623
Aggressive Growth 3 1.52 0.13 268,369
Core Growth 51 49.51 4.31 8,737,405
Growth 10 7.64 0.66 1,345,849
Income 9 4.11 0.36 724,288
Income Value 3 2.89 0.25 509,336
Yield 6 1.22 0.11 214,952
Index 31 265.68 23.11 46,815,669
Other 87 565.18 49.16 99,613,837
Broker Dealer 26 41.89 3.65 7,387,731
GARP 24 142.92 12.41 25,148,820
Hedge Fund 35 292.08 25.42 51,506,324
Specialty 1 3.82 0.33 673,048
Sector Specific 1 84.47 7.35 14,897,914
Value 42 100.52 8.81 17,851,444
Core Value 32 92.18 8.09 16,382,035
Deep Value 10 8.34 0.73 1,469,409

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
RA Capital Management, LP 18,417,458 9.09 -- 9/30/21
OrbiMed Advisors, LLC 14,897,914 7.35 1,961,292 9/30/21
The Vanguard Group, Inc. 14,611,623 7.21 -41,567 9/30/21
Wellington Management Company, LLP 14,068,108 6.94 -524,462 9/30/21
BlackRock Institutional Trust Company, N.A. 13,798,906 6.81 -1,733 9/30/21
State Street Global Advisors (US) 9,065,857 4.47 -1,654,074 9/30/21
Fidelity Institutional Asset Management 8,817,131 4.35 54,159 9/30/21
Redmile Group, LLC 8,258,345 4.08 -622,600 9/30/21
Adage Capital Management, L.P. 7,750,000 3.82 750,000 9/30/21
ClearBridge Investments, LLC 5,975,009 2.95 19,968 9/30/21
Two Sigma Investments, LP 4,214,388 2.08 -1,626,672 9/30/21
Geode Capital Management, L.L.C. 3,414,345 1.69 -218,231 9/30/21
Morgan Stanley & Co. LLC 3,149,517 1.55 -516,378 9/30/21
Banque Lombard Odier & Cie SA 3,013,467 1.49 358,629 9/30/21
Millennium Management LLC 2,947,521 1.45 324,613 9/30/21
Fidelity Management & Research Company LLC 2,747,756 1.36 35,198 9/30/21
Candriam Belgium S.A. 2,562,935 1.26 101,476 9/30/21
D. E. Shaw & Co., L.P. 2,086,235 1.03 -87,547 9/30/21
Northern Trust Investments, Inc. 1,834,092 0.91 -17,526 9/30/21
DWS Investments UK Limited 1,820,967 0.90 -3,247 9/30/21
Charles Schwab Investment Management, Inc. 1,406,002 0.69 -56,233 9/30/21
HOOPP Investment Management 1,402,800 0.69 -900,400 9/30/21
QVT Financial LP 1,375,900 0.68 -- 9/30/21
Rhenman & Partners Asset Management AB 1,218,850 0.60 -- 9/30/21
PanAgora Asset Management Inc. 1,147,194 0.57 21,109 9/30/21
Renaissance Technologies LLC 1,141,840 0.56 -942,250 9/30/21
Goldman Sachs & Company, Inc. 1,127,118 0.56 -110,767 9/30/21
Pinnacle Associates Ltd. 861,882 0.43 -29,845 9/30/21
Nuveen LLC 830,023 0.41 -64,892 9/30/21
PRIMECAP Management Company 788,927 0.39 -14,900 9/30/21
Point72 Asset Management, L.P. 714,700 0.35 714,700 9/30/21
Granahan Investment Management, Inc. 677,618 0.33 677,618 9/30/21
Managed Account Advisors LLC 673,048 0.33 -2,942 9/30/21
Norges Bank Investment Management (NBIM) 661,600 0.33 661,600 6/30/20
SilverArc Capital Management, LLC 649,919 0.32 -177,668 9/30/21
BlackRock Investment Management, LLC 616,133 0.30 -35,119 9/30/21
Morgan Stanley Smith Barney LLC 609,215 0.30 -8,789 9/30/21
Wells Fargo Advisors 592,433 0.29 -20,189 9/30/21
William Blair & Company, L.L.C. (Research) 515,600 0.25 691 9/30/21
BlackRock Financial Management, Inc. 504,513 0.25 12,546 9/30/21
BNY Mellon Asset Management 500,050 0.25 5,988 9/30/21
Tudor Investment Corporation 483,990 0.24 99,197 9/30/21
Voya Investment Management LLC 458,669 0.23 -33,055 9/30/21
Citi Investment Research (US) 451,926 0.22 -308,643 9/30/21
Schweizerische Nationalbank 441,800 0.22 13,400 9/30/21
Enyedy (Mark J) 432,866 0.21 3,849 6/30/21
AllianceBernstein L.P. 414,471 0.20 126,607 9/30/21
CM Management, LLC 375,000 0.19 -- 9/30/21
Pura Vida Investments, LLC 343,048 0.17 -346,001 9/30/21
State of Wisconsin Investment Board 307,900 0.15 14,800 9/30/21

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