Investors & Media

Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 297 1,204.89 88.11 183,132,896
Mutual Fund 239 255.08 19.88 39,779,195
Insider 10 6.96 0.55 1,134,209

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 130 132.02 9.64 20,039,601
Sellers 151 -158.80 11.45 -23,803,003
Net -26.78 1.81 -3,763,402

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 1,211.93 88.66 184,273,201
Top 10 Inst. 762.59 55.68 115,719,368
Top 20 Inst. 961.29 70.18 145,871,734
Top 50 Inst. 1,120.21 81.88 170,186,430

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 69 62.30 4.56 9,487,092
Aggressive Growth 3 2.06 0.15 313,147
Core Growth 54 54.95 4.03 8,367,753
Growth 12 5.29 0.39 806,192
Income 9 4.77 0.35 729,759
Income Value 2 3.26 0.24 494,872
Yield 7 1.51 0.11 234,887
Index 33 327.34 23.92 49,720,131
Other 94 673.36 49.16 102,172,821
Broker Dealer 28 52.45 3.83 7,959,466
GARP 27 171.95 12.56 26,096,186
Hedge Fund 37 359.24 26.22 54,504,557
Specialty 1 4.45 0.33 675,990
Sector Specific 1 85.25 6.22 12,936,622
Value 37 113.91 8.42 17,502,602
Core Value 29 108.66 8.04 16,704,110
Deep Value 8 5.24 0.38 798,492

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
RA Capital Management, LP 18,417,458 8.86 -- 6/30/21
The Vanguard Group, Inc. 14,653,190 7.05 346,051 6/30/21
Wellington Management Company, LLP 14,592,570 7.02 -4,410,910 6/30/21
BlackRock Institutional Trust Company, N.A. 13,800,639 6.64 -909,437 6/30/21
OrbiMed Advisors, LLC 12,936,622 6.22 3,804,800 6/30/21
State Street Global Advisors (US) 10,719,931 5.16 1,696,452 6/30/21
Redmile Group, LLC 8,880,945 4.27 -807,121 6/30/21
Fidelity Institutional Asset Management 8,762,972 4.22 -1,369,954 6/30/21
Adage Capital Management, L.P. 7,000,000 3.37 2,500,000 6/30/21
ClearBridge Investments, LLC 5,955,041 2.87 -153,644 6/30/21
Two Sigma Investments, LP 5,841,060 2.81 332,513 6/30/21
Morgan Stanley & Co. LLC 3,665,895 1.76 107,221 6/30/21
Geode Capital Management, L.L.C. 3,632,576 1.75 115,785 6/30/21
Fidelity Management & Research Company LLC 2,712,558 1.31 -688,866 6/30/21
Banque Lombard Odier & Cie SA 2,654,838 1.28 805,066 6/30/21
Millennium Management LLC 2,622,908 1.26 380,607 6/30/21
Candriam Belgium S.A. 2,461,459 1.18 2,461,459 6/30/21
HOOPP Investment Management 2,303,200 1.11 2,303,200 6/30/21
D. E. Shaw & Co., L.P. 2,173,782 1.05 342,538 6/30/21
Renaissance Technologies LLC 2,084,090 1.00 220,750 6/30/21
Northern Trust Investments, Inc. 1,851,618 0.89 -14,485 6/30/21
DWS Investments UK Limited 1,824,214 0.88 -954,704 6/30/21
Charles Schwab Investment Management, Inc. 1,462,235 0.70 24,635 6/30/21
QVT Financial LP 1,375,900 0.66 -- 6/30/21
Goldman Sachs & Company, Inc. 1,237,885 0.60 -879,936 6/30/21
Rhenman & Partners Asset Management AB 1,218,850 0.59 668,850 6/30/21
PanAgora Asset Management Inc. 1,126,085 0.54 -86,824 6/30/21
Nuveen LLC 894,915 0.43 -15,856 6/30/21
Pinnacle Associates Ltd. 891,727 0.43 13,669 6/30/21
SilverArc Capital Management, LLC 827,587 0.40 98,223 6/30/21
PRIMECAP Management Company 803,827 0.39 -42,300 6/30/21
Citi Investment Research (US) 760,569 0.37 148,652 6/30/21
Farallon Capital Management, L.L.C. 750,000 0.36 -- 6/30/21
Pura Vida Investments, LLC 689,049 0.33 -115,143 6/30/21
Managed Account Advisors LLC 675,990 0.33 -18,149 6/30/21
Norges Bank Investment Management (NBIM) 661,600 0.32 661,600 6/30/20
BlackRock Investment Management, LLC 651,252 0.31 -7,905 6/30/21
Citadel Advisors LLC 623,564 0.30 407,084 6/30/21
Morgan Stanley Smith Barney LLC 618,004 0.30 -26,629 6/30/21
Wells Fargo Advisors 612,622 0.29 -96,788 6/30/21
First Trust Advisors L.P. 586,115 0.28 4,863 6/30/21
Dimensional Fund Advisors, L.P. 529,821 0.25 529,821 6/30/21
William Blair & Company, L.L.C. (Research) 514,909 0.25 -891 6/30/21
BNY Mellon Asset Management 494,062 0.24 -1,053 6/30/21
BlackRock Financial Management, Inc. 491,967 0.24 -24,165 6/30/21
Voya Investment Management LLC 491,724 0.24 -18,132 6/30/21
Enyedy (Mark J) 432,866 0.21 3,849 6/30/21
Schweizerische Nationalbank 428,400 0.21 -- 6/30/21
Rafferty Asset Management LLC 402,546 0.19 24,784 6/30/21
Tudor Investment Corporation 384,793 0.19 310,721 6/30/21

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