| RA Capital Management, LP |
18,417,458 |
8.86 |
-- |
6/30/21 |
| The Vanguard Group, Inc. |
14,653,190 |
7.05 |
346,051 |
6/30/21 |
| Wellington Management Company, LLP |
14,592,570 |
7.02 |
-4,410,910 |
6/30/21 |
| BlackRock Institutional Trust Company, N.A. |
13,800,639 |
6.64 |
-909,437 |
6/30/21 |
| OrbiMed Advisors, LLC |
12,936,622 |
6.22 |
3,804,800 |
6/30/21 |
| State Street Global Advisors (US) |
10,719,931 |
5.16 |
1,696,452 |
6/30/21 |
| Redmile Group, LLC |
8,880,945 |
4.27 |
-807,121 |
6/30/21 |
| Fidelity Institutional Asset Management |
8,762,972 |
4.22 |
-1,369,954 |
6/30/21 |
| Adage Capital Management, L.P. |
7,000,000 |
3.37 |
2,500,000 |
6/30/21 |
| ClearBridge Investments, LLC |
5,955,041 |
2.87 |
-153,644 |
6/30/21 |
| Two Sigma Investments, LP |
5,841,060 |
2.81 |
332,513 |
6/30/21 |
| Morgan Stanley & Co. LLC |
3,665,895 |
1.76 |
107,221 |
6/30/21 |
| Geode Capital Management, L.L.C. |
3,632,576 |
1.75 |
115,785 |
6/30/21 |
| Fidelity Management & Research Company LLC |
2,712,558 |
1.31 |
-688,866 |
6/30/21 |
| Banque Lombard Odier & Cie SA |
2,654,838 |
1.28 |
805,066 |
6/30/21 |
| Millennium Management LLC |
2,622,908 |
1.26 |
380,607 |
6/30/21 |
| Candriam Belgium S.A. |
2,461,459 |
1.18 |
2,461,459 |
6/30/21 |
| HOOPP Investment Management |
2,303,200 |
1.11 |
2,303,200 |
6/30/21 |
| D. E. Shaw & Co., L.P. |
2,173,782 |
1.05 |
342,538 |
6/30/21 |
| Renaissance Technologies LLC |
2,084,090 |
1.00 |
220,750 |
6/30/21 |
| Northern Trust Investments, Inc. |
1,851,618 |
0.89 |
-14,485 |
6/30/21 |
| DWS Investments UK Limited |
1,824,214 |
0.88 |
-954,704 |
6/30/21 |
| Charles Schwab Investment Management, Inc. |
1,462,235 |
0.70 |
24,635 |
6/30/21 |
| QVT Financial LP |
1,375,900 |
0.66 |
-- |
6/30/21 |
| Goldman Sachs & Company, Inc. |
1,237,885 |
0.60 |
-879,936 |
6/30/21 |
| Rhenman & Partners Asset Management AB |
1,218,850 |
0.59 |
668,850 |
6/30/21 |
| PanAgora Asset Management Inc. |
1,126,085 |
0.54 |
-86,824 |
6/30/21 |
| Nuveen LLC |
894,915 |
0.43 |
-15,856 |
6/30/21 |
| Pinnacle Associates Ltd. |
891,727 |
0.43 |
13,669 |
6/30/21 |
| SilverArc Capital Management, LLC |
827,587 |
0.40 |
98,223 |
6/30/21 |
| PRIMECAP Management Company |
803,827 |
0.39 |
-42,300 |
6/30/21 |
| Citi Investment Research (US) |
760,569 |
0.37 |
148,652 |
6/30/21 |
| Farallon Capital Management, L.L.C. |
750,000 |
0.36 |
-- |
6/30/21 |
| Pura Vida Investments, LLC |
689,049 |
0.33 |
-115,143 |
6/30/21 |
| Managed Account Advisors LLC |
675,990 |
0.33 |
-18,149 |
6/30/21 |
| Norges Bank Investment Management (NBIM) |
661,600 |
0.32 |
661,600 |
6/30/20 |
| BlackRock Investment Management, LLC |
651,252 |
0.31 |
-7,905 |
6/30/21 |
| Citadel Advisors LLC |
623,564 |
0.30 |
407,084 |
6/30/21 |
| Morgan Stanley Smith Barney LLC |
618,004 |
0.30 |
-26,629 |
6/30/21 |
| Wells Fargo Advisors |
612,622 |
0.29 |
-96,788 |
6/30/21 |
| First Trust Advisors L.P. |
586,115 |
0.28 |
4,863 |
6/30/21 |
| Dimensional Fund Advisors, L.P. |
529,821 |
0.25 |
529,821 |
6/30/21 |
| William Blair & Company, L.L.C. (Research) |
514,909 |
0.25 |
-891 |
6/30/21 |
| BNY Mellon Asset Management |
494,062 |
0.24 |
-1,053 |
6/30/21 |
| BlackRock Financial Management, Inc. |
491,967 |
0.24 |
-24,165 |
6/30/21 |
| Voya Investment Management LLC |
491,724 |
0.24 |
-18,132 |
6/30/21 |
| Enyedy (Mark J) |
432,866 |
0.21 |
3,849 |
6/30/21 |
| Schweizerische Nationalbank |
428,400 |
0.21 |
-- |
6/30/21 |
| Rafferty Asset Management LLC |
402,546 |
0.19 |
24,784 |
6/30/21 |
| Tudor Investment Corporation |
384,793 |
0.19 |
310,721 |
6/30/21 |