Investors & Media

Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 316 1,009.06 94.65 208,933,427
Mutual Fund 245 223.63 19.34 42,626,633
Insider 11 4.46 0.41 914,554

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 150 124.45 11.72 25,863,058
Sellers 133 -96.58 9.24 -20,386,530
Net 27.86 2.48 5,476,528

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 1,013.52 95.06 209,847,981
Top 10 Inst. 582.75 55.04 121,495,604
Top 20 Inst. 731.21 68.52 151,264,041
Top 50 Inst. 890.91 83.52 184,369,433

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 68 123.39 11.65 25,722,407
Aggressive Growth 2 0.87 0.08 181,467
Core Growth 52 63.19 5.97 13,184,590
Growth 14 59.33 5.60 12,356,350
Income 6 3.70 0.35 773,130
Income Value 3 3.69 0.35 771,618
Yield 3 0.01 -- 1,512
Index 31 263.90 24.99 55,163,739
Other 111 508.76 47.83 105,581,051
Broker Dealer 27 40.33 3.82 8,438,070
GARP 31 85.45 7.90 17,444,632
Hedge Fund 48 376.16 35.46 78,272,938
Specialty 4 4.41 0.42 923,018
VC Private Equity 1 2.40 0.23 502,393
Value 37 91.15 8.14 17,958,853
Core Value 29 75.38 6.65 14,671,287
Deep Value 8 15.77 1.49 3,287,566

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
RA Capital Management, LP 21,741,458 9.85 -- 9/30/22
The Vanguard Group, Inc. 15,594,861 7.06 -434,172 9/30/22
State Street Global Advisors (US) 14,594,873 6.61 -3,604,681 9/30/22
BlackRock Institutional Trust Company, N.A. 14,514,902 6.58 -444,330 9/30/22
Deerfield Management Company, L.P. 13,740,205 6.22 -1,280,285 9/30/22
Adage Capital Management, L.P. 11,119,000 5.04 3,219,000 12/15/22
Wellington Management Company, LLP 10,007,505 4.53 -709,580 9/30/22
Redmile Group, LLC 8,548,145 3.87 -592,900 9/30/22
Jennison Associates LLC 6,197,480 2.81 6,197,480 9/30/22
Two Sigma Investments, LP 5,437,175 2.46 584,730 9/30/22
ClearBridge Investments, LLC 4,825,543 2.19 -546,522 9/30/22
Geode Capital Management, L.L.C. 3,707,278 1.68 21,497 9/30/22
Maverick Capital, Ltd. 3,553,128 1.61 786,654 9/30/22
Morgan Stanley & Co. LLC 2,989,596 1.35 -773,898 9/30/22
DWS Investments UK Limited 2,902,989 1.32 -14,064 9/30/22
Candriam Belgium S.A. 2,854,635 1.29 1,798,196 9/30/22
Candriam Luxembourg S.A. 2,582,557 1.17 -- 11/30/22
Dimensional Fund Advisors, L.P. 2,540,851 1.15 929,775 9/30/22
Norges Bank Investment Management (NBIM) 1,934,900 0.88 1,934,900 12/31/21
Granahan Investment Management, Inc. 1,876,960 0.85 -4,836 9/30/22
Millennium Management LLC 1,840,837 0.83 -3,216,212 9/30/22
Northern Trust Investments, Inc. 1,803,756 0.82 -24,747 9/30/22
Renaissance Technologies LLC 1,705,140 0.77 256,400 9/30/22
Charles Schwab Investment Management, Inc. 1,525,106 0.69 60,887 9/30/22
Tang Capital Management, LLC 1,500,000 0.68 -- 9/30/22
Citadel Advisors LLC 1,440,409 0.65 -409,632 9/30/22
QVT Financial LP 1,375,900 0.62 -- 9/30/22
Pinnacle Associates Ltd. 1,327,068 0.60 -21,895 12/31/22
BlackRock Financial Management, Inc. 1,320,149 0.60 -13,030 9/30/22
Janus Henderson Investors 1,310,492 0.59 1,090,132 9/30/22
HealthCor Management, L.P. 1,300,000 0.59 800,000 9/30/22
Rhenman & Partners Asset Management AB 1,100,000 0.50 -100,000 9/30/22
PanAgora Asset Management Inc. 1,081,008 0.49 -80,205 9/30/22
Voya Investment Management LLC 1,032,501 0.47 946,412 9/30/22
Putnam Investment Management, L.L.C. 1,031,092 0.47 820,722 9/30/22
Fidelity Management & Research Company LLC 1,007,829 0.46 3,746 9/30/22
Rafferty Asset Management LLC 947,451 0.43 199,435 9/30/22
Lombard Odier Asset Management (Europe) Ltd 936,608 0.42 -10,889 10/31/22
Banque Lombard Odier & Cie SA 936,501 0.42 -68,125 9/30/22
Citi Investment Research (US) 904,498 0.41 101,213 9/30/22
Morgan Stanley Smith Barney LLC 880,913 0.40 3,241 9/30/22
Segall Bryant & Hamill, LLC 878,961 0.40 24,315 9/30/22
Goldman Sachs & Company, Inc. 872,647 0.40 187,506 9/30/22
Sectoral Asset Management Inc. 848,744 0.38 -91,500 9/30/22
BlackRock Advisors (UK) Limited 730,385 0.33 13,537 12/31/22
PRIMECAP Management Company 728,327 0.33 -- 9/30/22
BlackRock Asset Management Ireland Limited 697,042 0.32 15,940 9/30/22
FundLogic SAS 688,051 0.31 -- 9/30/22
D. E. Shaw & Co., L.P. 679,132 0.31 -297,795 9/30/22
Monarch Partners Asset Management LLC 674,845 0.31 674,845 9/30/22

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