| The Vanguard Group, Inc. |
24,438,531 |
9.13 |
3,583,129 |
9/30/23 |
| Janus Henderson Investors |
17,684,816 |
6.61 |
2,185,028 |
9/30/23 |
| Redmile Group, LLC |
17,503,417 |
6.54 |
-227,000 |
9/30/23 |
| BlackRock Institutional Trust Company, N.A. |
16,852,893 |
6.30 |
-245,499 |
9/30/23 |
| RA Capital Management, LP |
13,322,288 |
4.98 |
10,992,330 |
9/30/23 |
| Wellington Management Company, LLP |
13,258,997 |
4.95 |
3,506,098 |
9/30/23 |
| State Street Global Advisors (US) |
9,551,852 |
3.57 |
1,612,938 |
9/30/23 |
| D. E. Shaw & Co., L.P. |
6,995,239 |
2.61 |
714,723 |
9/30/23 |
| Fairmount Funds Management LLC |
5,929,592 |
2.22 |
-100,000 |
9/30/23 |
| Fidelity Management & Research Company LLC |
5,779,943 |
2.16 |
190,101 |
9/30/23 |
| Geode Capital Management, L.L.C. |
4,899,975 |
1.83 |
147,425 |
9/30/23 |
| T. Rowe Price Associates, Inc. |
3,775,174 |
1.41 |
1,575,317 |
9/30/23 |
| Artisan Partners Limited Partnership |
3,724,583 |
1.39 |
-1,338 |
9/30/23 |
| Pictet Asset Management Ltd. |
3,708,139 |
1.39 |
2,987,064 |
9/30/23 |
| Emerald Advisers LLC |
3,277,369 |
1.22 |
1,476,678 |
9/30/23 |
| Hood River Capital Management LLC |
3,044,485 |
1.14 |
60,814 |
9/30/23 |
| Boxer Capital, L.L.C. |
2,961,000 |
1.11 |
-- |
9/30/23 |
| Two Sigma Investments, LP |
2,922,735 |
1.09 |
921,080 |
9/30/23 |
| Nuveen LLC |
2,886,241 |
1.08 |
243,707 |
9/30/23 |
| Maverick Capital, Ltd. |
2,518,527 |
0.94 |
-1,268,371 |
9/30/23 |
| Voloridge Investment Management, LLC |
2,512,251 |
0.94 |
481,296 |
9/30/23 |
| Woodline Partners LP |
2,433,161 |
0.91 |
-114,478 |
9/30/23 |
| Morgan Stanley & Co. LLC |
2,144,953 |
0.80 |
-598,051 |
9/30/23 |
| Nicholas Investment Partners, L.P. |
2,067,561 |
0.77 |
843,434 |
9/30/23 |
| Sofinnova Investments, Inc |
2,045,202 |
0.76 |
1,217,884 |
9/30/23 |
| Morgan Stanley Investment Management Inc. (US) |
2,031,997 |
0.76 |
1,959,891 |
9/30/23 |
| Northern Trust Investments, Inc. |
2,010,802 |
0.75 |
-17,129 |
9/30/23 |
| Medical Strategy GmbH |
1,943,763 |
0.73 |
91,000 |
7/31/23 |
| Avidity Partners Management LP |
1,917,907 |
0.72 |
-79,893 |
9/30/23 |
| Charles Schwab Investment Management, Inc. |
1,830,575 |
0.68 |
20,113 |
9/30/23 |
| Millennium Management LLC |
1,605,714 |
0.60 |
-1,092,149 |
9/30/23 |
| Invus Public Equities Advisors, LLC |
1,512,113 |
0.56 |
746,616 |
9/30/23 |
| BlackRock Financial Management, Inc. |
1,503,127 |
0.56 |
-275,486 |
9/30/23 |
| Tang Capital Management, LLC |
1,500,000 |
0.56 |
200,000 |
9/30/23 |
| Driehaus Capital Management, LLC |
1,440,052 |
0.54 |
263,922 |
9/30/23 |
| QVT Financial LP |
1,375,900 |
0.51 |
-- |
9/30/23 |
| SilverArc Capital Management, LLC |
1,307,435 |
0.49 |
-112,565 |
9/30/23 |
| Eventide Asset Management, LLC |
1,300,000 |
0.49 |
-- |
9/30/23 |
| Citadel Advisors LLC |
1,287,542 |
0.48 |
359,302 |
9/30/23 |
| J.P. Morgan Securities LLC |
1,236,730 |
0.46 |
727,583 |
9/30/23 |
| Dimensional Fund Advisors, L.P. |
1,180,744 |
0.44 |
-8,475 |
9/30/23 |
| Candriam Luxembourg S.A. |
1,177,557 |
0.44 |
75,000 |
10/31/23 |
| Candriam Belgium S.A. |
1,122,588 |
0.42 |
130,006 |
9/30/23 |
| PanAgora Asset Management Inc. |
1,098,417 |
0.41 |
-19,552 |
9/30/23 |
| Pinnacle Associates Ltd. |
1,016,156 |
0.38 |
-193,767 |
9/30/23 |
| Principal Global Investors (Equity) |
984,664 |
0.37 |
-3,222 |
9/30/23 |
| Susquehanna International Group, LLP |
974,887 |
0.36 |
-340,771 |
9/30/23 |
| Lombard Odier Asset Management (Europe) Ltd |
936,608 |
0.35 |
-10,889 |
10/31/22 |
| BlackRock Asset Management Ireland Limited |
919,710 |
0.34 |
-41,163 |
9/30/23 |
| BlackRock Advisors (UK) Limited |
919,605 |
0.34 |
2,422 |
11/30/23 |