| Wellington Management Company, LLP |
23,311,638 |
13.36 |
4,160,256 |
6/30/20 |
| The Vanguard Group, Inc. |
14,904,994 |
8.54 |
-1,137,790 |
6/30/20 |
| BlackRock Institutional Trust Company, N.A. |
12,910,298 |
7.40 |
559,934 |
6/30/20 |
| Redmile Group, LLC |
12,006,979 |
6.88 |
-4,726,900 |
6/30/20 |
| Renaissance Technologies LLC |
9,665,139 |
5.54 |
-1,350,990 |
6/30/20 |
| State Street Global Advisors (US) |
9,183,306 |
5.26 |
3,457,441 |
6/30/20 |
| ClearBridge Investments, LLC |
7,742,804 |
4.44 |
-564,260 |
6/30/20 |
| Millennium Management LLC |
3,985,994 |
2.28 |
2,007,736 |
6/30/20 |
| Geode Capital Management, L.L.C. |
2,795,189 |
1.60 |
60,434 |
6/30/20 |
| D. E. Shaw & Co., L.P. |
2,562,656 |
1.47 |
220,406 |
6/30/20 |
| Two Sigma Investments, LP |
2,189,271 |
1.25 |
76,443 |
6/30/20 |
| Northern Trust Investments, Inc. |
1,959,757 |
1.12 |
62,686 |
6/30/20 |
| PanAgora Asset Management Inc. |
1,828,760 |
1.05 |
228,682 |
6/30/20 |
| Fidelity Management & Research Company LLC |
1,573,863 |
0.90 |
115 |
6/30/20 |
| Columbia Wanger Asset Management, LLC |
1,414,000 |
0.81 |
333,000 |
6/30/20 |
| QVT Financial LP |
1,375,900 |
0.79 |
-- |
6/30/20 |
| Invesco Capital Management LLC |
1,311,413 |
0.75 |
1,311,250 |
6/30/20 |
| HealthCor Management, L.P. |
1,200,000 |
0.69 |
1,200,000 |
6/30/20 |
| Goldman Sachs & Company, Inc. |
1,194,161 |
0.68 |
781,533 |
6/30/20 |
| Charles Schwab Investment Management, Inc. |
1,160,095 |
0.66 |
85,155 |
6/30/20 |
| Pinnacle Associates Ltd. |
1,087,034 |
0.62 |
-10,971 |
6/30/20 |
| Wells Fargo Advisors |
980,223 |
0.56 |
-57,607 |
6/30/20 |
| PRIMECAP Management Company |
943,127 |
0.54 |
-55,000 |
6/30/20 |
| Nuveen LLC |
904,296 |
0.52 |
-343,120 |
6/30/20 |
| Managed Account Advisors LLC |
848,895 |
0.49 |
-112,604 |
6/30/20 |
| HOOPP Investment Management |
842,695 |
0.48 |
-82,000 |
6/30/20 |
| DWS Investments UK Limited |
732,710 |
0.42 |
-510,832 |
6/30/20 |
| BlackRock Investment Management, LLC |
716,574 |
0.41 |
99,135 |
6/30/20 |
| Arrowstreet Capital, Limited Partnership |
679,401 |
0.39 |
61,712 |
6/30/20 |
| Allianz Global Investors U.S. LLC |
655,320 |
0.38 |
382,994 |
6/30/20 |
| BlackRock Financial Management, Inc. |
605,029 |
0.35 |
119,111 |
6/30/20 |
| Morgan Stanley Smith Barney LLC |
590,243 |
0.34 |
-45,264 |
6/30/20 |
| Jacobs Levy Equity Management, Inc. |
561,172 |
0.32 |
-109,035 |
6/30/20 |
| Goldman Sachs Asset Management (US) |
527,395 |
0.30 |
-56,639 |
6/30/20 |
| BNY Mellon Asset Management |
480,774 |
0.28 |
-14,229 |
6/30/20 |
| Medical Strategy GmbH |
462,424 |
0.26 |
-- |
7/31/20 |
| Enyedy (Mark J) |
439,017 |
0.25 |
5,241 |
6/30/20 |
| Schweizerische Nationalbank |
386,600 |
0.22 |
54,900 |
6/30/20 |
| California Public Employees' Retirement System |
385,632 |
0.22 |
55,968 |
6/30/20 |
| PDT Partners, LLC |
348,300 |
0.20 |
-70,400 |
6/30/20 |
| AQR Capital Management, LLC |
347,314 |
0.20 |
69,186 |
6/30/20 |
| Citi Investment Research (US) |
313,433 |
0.18 |
32,931 |
6/30/20 |
| Raymond James & Associates, Inc. |
313,307 |
0.18 |
16,081 |
6/30/20 |
| Gotham Asset Management, LLC |
302,829 |
0.17 |
199,583 |
6/30/20 |
| AllianceBernstein L.P. |
297,564 |
0.17 |
6,600 |
6/30/20 |
| Mellon Investments Corporation |
295,224 |
0.17 |
49,394 |
6/30/20 |
| Rhumbline Advisers Ltd. Partnership |
289,701 |
0.17 |
60,384 |
6/30/20 |
| Thrivent Asset Management, LLC |
287,704 |
0.16 |
-- |
6/30/20 |
| Credit Suisse Securities (USA) LLC |
285,689 |
0.16 |
278,628 |
6/30/20 |
| Barclays Bank PLC |
280,008 |
0.16 |
157,169 |
6/30/20 |