RA Capital Management, LP |
21,741,458 |
9.85 |
-- |
9/30/22 |
The Vanguard Group, Inc. |
15,594,861 |
7.06 |
-434,172 |
9/30/22 |
State Street Global Advisors (US) |
14,594,873 |
6.61 |
-3,604,681 |
9/30/22 |
BlackRock Institutional Trust Company, N.A. |
14,514,902 |
6.58 |
-444,330 |
9/30/22 |
Deerfield Management Company, L.P. |
13,740,205 |
6.22 |
-1,280,285 |
9/30/22 |
Adage Capital Management, L.P. |
11,119,000 |
5.04 |
3,219,000 |
12/15/22 |
Wellington Management Company, LLP |
10,007,505 |
4.53 |
-709,580 |
9/30/22 |
Redmile Group, LLC |
8,548,145 |
3.87 |
-592,900 |
9/30/22 |
Jennison Associates LLC |
6,197,480 |
2.81 |
6,197,480 |
9/30/22 |
Two Sigma Investments, LP |
5,437,175 |
2.46 |
584,730 |
9/30/22 |
ClearBridge Investments, LLC |
4,825,543 |
2.19 |
-546,522 |
9/30/22 |
Geode Capital Management, L.L.C. |
3,707,278 |
1.68 |
21,497 |
9/30/22 |
Maverick Capital, Ltd. |
3,553,128 |
1.61 |
786,654 |
9/30/22 |
Morgan Stanley & Co. LLC |
2,989,596 |
1.35 |
-773,898 |
9/30/22 |
DWS Investments UK Limited |
2,902,989 |
1.32 |
-14,064 |
9/30/22 |
Candriam Belgium S.A. |
2,854,635 |
1.29 |
1,798,196 |
9/30/22 |
Candriam Luxembourg S.A. |
2,582,557 |
1.17 |
-- |
11/30/22 |
Dimensional Fund Advisors, L.P. |
2,540,851 |
1.15 |
929,775 |
9/30/22 |
Norges Bank Investment Management (NBIM) |
1,934,900 |
0.88 |
1,934,900 |
12/31/21 |
Granahan Investment Management, Inc. |
1,876,960 |
0.85 |
-4,836 |
9/30/22 |
Millennium Management LLC |
1,840,837 |
0.83 |
-3,216,212 |
9/30/22 |
Northern Trust Investments, Inc. |
1,803,756 |
0.82 |
-24,747 |
9/30/22 |
Renaissance Technologies LLC |
1,705,140 |
0.77 |
256,400 |
9/30/22 |
Charles Schwab Investment Management, Inc. |
1,525,106 |
0.69 |
60,887 |
9/30/22 |
Tang Capital Management, LLC |
1,500,000 |
0.68 |
-- |
9/30/22 |
Citadel Advisors LLC |
1,440,409 |
0.65 |
-409,632 |
9/30/22 |
QVT Financial LP |
1,375,900 |
0.62 |
-- |
9/30/22 |
Pinnacle Associates Ltd. |
1,327,068 |
0.60 |
-21,895 |
12/31/22 |
BlackRock Financial Management, Inc. |
1,320,149 |
0.60 |
-13,030 |
9/30/22 |
Janus Henderson Investors |
1,310,492 |
0.59 |
1,090,132 |
9/30/22 |
HealthCor Management, L.P. |
1,300,000 |
0.59 |
800,000 |
9/30/22 |
Rhenman & Partners Asset Management AB |
1,100,000 |
0.50 |
-100,000 |
9/30/22 |
PanAgora Asset Management Inc. |
1,081,008 |
0.49 |
-80,205 |
9/30/22 |
Voya Investment Management LLC |
1,032,501 |
0.47 |
946,412 |
9/30/22 |
Putnam Investment Management, L.L.C. |
1,031,092 |
0.47 |
820,722 |
9/30/22 |
Fidelity Management & Research Company LLC |
1,007,829 |
0.46 |
3,746 |
9/30/22 |
Rafferty Asset Management LLC |
947,451 |
0.43 |
199,435 |
9/30/22 |
Lombard Odier Asset Management (Europe) Ltd |
936,608 |
0.42 |
-10,889 |
10/31/22 |
Banque Lombard Odier & Cie SA |
936,501 |
0.42 |
-68,125 |
9/30/22 |
Citi Investment Research (US) |
904,498 |
0.41 |
101,213 |
9/30/22 |
Morgan Stanley Smith Barney LLC |
880,913 |
0.40 |
3,241 |
9/30/22 |
Segall Bryant & Hamill, LLC |
878,961 |
0.40 |
24,315 |
9/30/22 |
Goldman Sachs & Company, Inc. |
872,647 |
0.40 |
187,506 |
9/30/22 |
Sectoral Asset Management Inc. |
848,744 |
0.38 |
-91,500 |
9/30/22 |
BlackRock Advisors (UK) Limited |
730,385 |
0.33 |
13,537 |
12/31/22 |
PRIMECAP Management Company |
728,327 |
0.33 |
-- |
9/30/22 |
BlackRock Asset Management Ireland Limited |
697,042 |
0.32 |
15,940 |
9/30/22 |
FundLogic SAS |
688,051 |
0.31 |
-- |
9/30/22 |
D. E. Shaw & Co., L.P. |
679,132 |
0.31 |
-297,795 |
9/30/22 |
Monarch Partners Asset Management LLC |
674,845 |
0.31 |
674,845 |
9/30/22 |