Investors & Media

Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 308 958.74 90.49 199,564,112
Mutual Fund 241 265.81 19.47 41,891,854
Insider 10 5.25 0.45 992,533

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 148 159.85 14.83 32,695,134
Sellers 152 -145.08 12.72 -28,056,485
Net 14.77 2.10 4,638,649

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 963.14 90.86 200,379,084
Top 10 Inst. 565.71 53.89 118,847,365
Top 20 Inst. 703.20 66.99 147,730,627
Top 50 Inst. 863.94 81.81 180,418,274

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 66 95.54 9.05 19,965,791
Aggressive Growth 4 2.45 0.23 514,594
Core Growth 52 65.05 6.15 13,561,158
Growth 10 28.05 2.67 5,890,039
Income 7 3.24 0.31 679,961
Income Value 3 3.22 0.31 676,228
Yield 4 0.02 -- 3,733
Index 31 254.86 24.23 53,431,670
Other 93 483.42 45.90 101,221,514
Broker Dealer 26 39.29 3.74 8,254,680
GARP 24 114.22 10.74 23,675,144
Hedge Fund 40 319.89 30.46 67,185,209
Specialty 2 3.23 0.31 678,312
VC Private Equity 1 6.80 0.65 1,428,169
Sector Specific -- -- -- --
Value 39 94.01 8.42 18,561,075
Core Value 32 90.83 8.11 17,895,127
Deep Value 7 3.18 0.30 665,948

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
RA Capital Management, LP 21,741,458 9.86 1,500,000 3/31/22
The Vanguard Group, Inc. 15,478,516 7.02 346,764 3/31/22
BlackRock Institutional Trust Company, N.A. 14,494,466 6.57 1,181,769 3/31/22
State Street Global Advisors (US) 13,707,389 6.22 5,638,822 3/31/22
Wellington Management Company, LLP 13,063,484 5.92 -839,014 3/31/22
Adage Capital Management, L.P. 11,586,193 5.25 1,300,000 3/31/22
Fidelity Institutional Asset Management 9,507,321 4.31 435,330 3/31/22
Redmile Group, LLC 9,217,945 4.18 959,600 3/31/22
ClearBridge Investments, LLC 5,502,843 2.50 -384,087 3/31/22
Two Sigma Investments, LP 4,547,750 2.06 -173,342 3/31/22
Morgan Stanley & Co. LLC 3,687,542 1.67 858,587 3/31/22
Millennium Management LLC 3,500,017 1.59 -1,549,274 3/31/22
Geode Capital Management, L.L.C. 3,489,369 1.58 -57,398 3/31/22
Deerfield Management Company, L.P. 3,470,675 1.57 3,470,675 3/31/22
DWS Investments UK Limited 2,931,776 1.33 1,104,077 3/31/22
Deutsche Asset Management Americas 2,813,676 1.28 2,813,676 3/31/22
Fidelity Management & Research Company LLC 2,567,022 1.16 -635,810 3/31/22
Banque Lombard Odier & Cie SA 2,275,409 1.03 -1,168,115 3/31/22
Nuveen LLC 2,190,057 0.99 1,415,091 3/31/22
Granahan Investment Management, Inc. 1,957,719 0.89 691,029 3/31/22
Norges Bank Investment Management (NBIM) 1,934,900 0.88 1,273,300 12/31/21
Northern Trust Investments, Inc. 1,886,224 0.86 52,328 3/31/22
Lynx1 Capital Advisors LLC 1,543,259 0.70 -586,272 3/31/22
Charles Schwab Investment Management, Inc. 1,500,219 0.68 78,296 3/31/22
Tang Capital Management, LLC 1,500,000 0.68 -- 3/31/22
Renaissance Technologies LLC 1,462,340 0.66 244,953 3/31/22
Sofinnova Investments, Inc 1,428,169 0.65 -321,713 3/31/22
Rhenman & Partners Asset Management AB 1,425,000 0.65 -75,000 3/31/22
Pinnacle Associates Ltd. 1,404,668 0.64 218,610 3/31/22
QVT Financial LP 1,375,900 0.62 -- 3/31/22
HealthCor Management, L.P. 1,310,340 0.59 -- 3/31/22
D. E. Shaw & Co., L.P. 1,251,677 0.57 -606,029 3/31/22
Janus Henderson Investors 1,238,327 0.56 814,464 3/31/22
PanAgora Asset Management Inc. 1,173,855 0.53 39,385 3/31/22
Eventide Asset Management, LLC 1,000,000 0.45 -- 3/31/22
Altium Capital Management LP 920,000 0.42 920,000 3/31/22
Sectoral Asset Management Inc. 878,844 0.40 878,844 3/31/22
Morgan Stanley Smith Barney LLC 863,963 0.39 178,717 3/31/22
Rafferty Asset Management LLC 852,884 0.39 439,850 3/31/22
Segall Bryant & Hamill, LLC 844,163 0.38 826,003 3/31/22
BofA Global Research (US) 822,190 0.37 398,047 3/31/22
BlackRock Financial Management, Inc. 788,753 0.36 303,400 3/31/22
PRIMECAP Management Company 756,827 0.34 -4,900 3/31/22
Citadel Advisors LLC 737,668 0.33 -397,483 3/31/22
FundLogic SAS 688,051 0.31 -- 3/31/22
SilverArc Capital Management, LLC 645,000 0.29 -869,411 3/31/22
Managed Account Advisors LLC 638,242 0.29 -21,480 3/31/22
BlackRock Investment Management, LLC 623,246 0.28 25,774 3/31/22
Wells Fargo Advisors 614,436 0.28 45,248 3/31/22
UBS Financial Services, Inc. 578,502 0.26 276,405 3/31/22

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