RA Capital Management, LP |
21,741,458 |
9.86 |
1,500,000 |
3/31/22 |
The Vanguard Group, Inc. |
15,478,516 |
7.02 |
346,764 |
3/31/22 |
BlackRock Institutional Trust Company, N.A. |
14,494,466 |
6.57 |
1,181,769 |
3/31/22 |
State Street Global Advisors (US) |
13,707,389 |
6.22 |
5,638,822 |
3/31/22 |
Wellington Management Company, LLP |
13,063,484 |
5.92 |
-839,014 |
3/31/22 |
Adage Capital Management, L.P. |
11,586,193 |
5.25 |
1,300,000 |
3/31/22 |
Fidelity Institutional Asset Management |
9,507,321 |
4.31 |
435,330 |
3/31/22 |
Redmile Group, LLC |
9,217,945 |
4.18 |
959,600 |
3/31/22 |
ClearBridge Investments, LLC |
5,502,843 |
2.50 |
-384,087 |
3/31/22 |
Two Sigma Investments, LP |
4,547,750 |
2.06 |
-173,342 |
3/31/22 |
Morgan Stanley & Co. LLC |
3,687,542 |
1.67 |
858,587 |
3/31/22 |
Millennium Management LLC |
3,500,017 |
1.59 |
-1,549,274 |
3/31/22 |
Geode Capital Management, L.L.C. |
3,489,369 |
1.58 |
-57,398 |
3/31/22 |
Deerfield Management Company, L.P. |
3,470,675 |
1.57 |
3,470,675 |
3/31/22 |
DWS Investments UK Limited |
2,931,776 |
1.33 |
1,104,077 |
3/31/22 |
Deutsche Asset Management Americas |
2,813,676 |
1.28 |
2,813,676 |
3/31/22 |
Fidelity Management & Research Company LLC |
2,567,022 |
1.16 |
-635,810 |
3/31/22 |
Banque Lombard Odier & Cie SA |
2,275,409 |
1.03 |
-1,168,115 |
3/31/22 |
Nuveen LLC |
2,190,057 |
0.99 |
1,415,091 |
3/31/22 |
Granahan Investment Management, Inc. |
1,957,719 |
0.89 |
691,029 |
3/31/22 |
Norges Bank Investment Management (NBIM) |
1,934,900 |
0.88 |
1,273,300 |
12/31/21 |
Northern Trust Investments, Inc. |
1,886,224 |
0.86 |
52,328 |
3/31/22 |
Lynx1 Capital Advisors LLC |
1,543,259 |
0.70 |
-586,272 |
3/31/22 |
Charles Schwab Investment Management, Inc. |
1,500,219 |
0.68 |
78,296 |
3/31/22 |
Tang Capital Management, LLC |
1,500,000 |
0.68 |
-- |
3/31/22 |
Renaissance Technologies LLC |
1,462,340 |
0.66 |
244,953 |
3/31/22 |
Sofinnova Investments, Inc |
1,428,169 |
0.65 |
-321,713 |
3/31/22 |
Rhenman & Partners Asset Management AB |
1,425,000 |
0.65 |
-75,000 |
3/31/22 |
Pinnacle Associates Ltd. |
1,404,668 |
0.64 |
218,610 |
3/31/22 |
QVT Financial LP |
1,375,900 |
0.62 |
-- |
3/31/22 |
HealthCor Management, L.P. |
1,310,340 |
0.59 |
-- |
3/31/22 |
D. E. Shaw & Co., L.P. |
1,251,677 |
0.57 |
-606,029 |
3/31/22 |
Janus Henderson Investors |
1,238,327 |
0.56 |
814,464 |
3/31/22 |
PanAgora Asset Management Inc. |
1,173,855 |
0.53 |
39,385 |
3/31/22 |
Eventide Asset Management, LLC |
1,000,000 |
0.45 |
-- |
3/31/22 |
Altium Capital Management LP |
920,000 |
0.42 |
920,000 |
3/31/22 |
Sectoral Asset Management Inc. |
878,844 |
0.40 |
878,844 |
3/31/22 |
Morgan Stanley Smith Barney LLC |
863,963 |
0.39 |
178,717 |
3/31/22 |
Rafferty Asset Management LLC |
852,884 |
0.39 |
439,850 |
3/31/22 |
Segall Bryant & Hamill, LLC |
844,163 |
0.38 |
826,003 |
3/31/22 |
BofA Global Research (US) |
822,190 |
0.37 |
398,047 |
3/31/22 |
BlackRock Financial Management, Inc. |
788,753 |
0.36 |
303,400 |
3/31/22 |
PRIMECAP Management Company |
756,827 |
0.34 |
-4,900 |
3/31/22 |
Citadel Advisors LLC |
737,668 |
0.33 |
-397,483 |
3/31/22 |
FundLogic SAS |
688,051 |
0.31 |
-- |
3/31/22 |
SilverArc Capital Management, LLC |
645,000 |
0.29 |
-869,411 |
3/31/22 |
Managed Account Advisors LLC |
638,242 |
0.29 |
-21,480 |
3/31/22 |
BlackRock Investment Management, LLC |
623,246 |
0.28 |
25,774 |
3/31/22 |
Wells Fargo Advisors |
614,436 |
0.28 |
45,248 |
3/31/22 |
UBS Financial Services, Inc. |
578,502 |
0.26 |
276,405 |
3/31/22 |