| Wellington Management Company, LLP |
22,084,103 |
11.34 |
-996,025 |
12/31/20 |
| RA Capital Management, LP |
18,417,458 |
9.46 |
11,376,973 |
12/31/20 |
| The Vanguard Group, Inc. |
14,157,000 |
7.27 |
-31,530 |
12/31/20 |
| BlackRock Institutional Trust Company, N.A. |
13,704,023 |
7.04 |
1,433,848 |
12/31/20 |
| Redmile Group, LLC |
10,528,179 |
5.41 |
50,300 |
12/31/20 |
| State Street Global Advisors (US) |
8,803,841 |
4.52 |
-160,165 |
12/31/20 |
| Fidelity Institutional Asset Management |
8,796,597 |
4.52 |
8,706,797 |
12/31/20 |
| ClearBridge Investments, LLC |
6,892,928 |
3.54 |
-557,564 |
12/31/20 |
| Two Sigma Investments, LP |
4,668,788 |
2.40 |
1,040,528 |
12/31/20 |
| Renaissance Technologies LLC |
4,235,966 |
2.18 |
-2,253,173 |
12/31/20 |
| Morgan Stanley & Co. LLC |
4,021,785 |
2.07 |
4,006,223 |
12/31/20 |
| Fidelity Management & Research Company LLC |
3,746,017 |
1.92 |
2,171,956 |
12/31/20 |
| Consonance Capital Management LP |
3,515,944 |
1.81 |
3,515,944 |
12/31/20 |
| Geode Capital Management, L.L.C. |
3,046,603 |
1.56 |
275,364 |
12/31/20 |
| DWS Investments UK Limited |
2,787,677 |
1.43 |
1,143,153 |
12/31/20 |
| OrbiMed Advisors, LLC |
2,553,900 |
1.31 |
2,553,900 |
12/31/20 |
| Goldman Sachs & Company, Inc. |
2,521,843 |
1.30 |
1,675,763 |
12/31/20 |
| Adage Capital Management, L.P. |
2,475,000 |
1.27 |
2,475,000 |
12/31/20 |
| Millennium Management LLC |
1,953,474 |
1.00 |
-2,801,900 |
12/31/20 |
| Northern Trust Investments, Inc. |
1,896,509 |
0.97 |
22,797 |
12/31/20 |
| Columbia Wanger Asset Management, LLC |
1,841,000 |
0.95 |
427,000 |
12/31/20 |
| Citadel Advisors LLC |
1,734,847 |
0.89 |
1,097,928 |
12/31/20 |
| Marshall Wace LLP |
1,574,738 |
0.81 |
1,574,738 |
12/31/20 |
| QVT Financial LP |
1,375,900 |
0.71 |
-- |
12/31/20 |
| PanAgora Asset Management Inc. |
1,313,077 |
0.67 |
152,565 |
12/31/20 |
| D. E. Shaw & Co., L.P. |
1,255,682 |
0.64 |
-385,734 |
12/31/20 |
| Charles Schwab Investment Management, Inc. |
1,227,636 |
0.63 |
87,663 |
12/31/20 |
| Farallon Capital Management, L.L.C. |
1,000,000 |
0.51 |
1,000,000 |
12/31/20 |
| Pinnacle Associates Ltd. |
975,418 |
0.50 |
-65,013 |
12/31/20 |
| PRIMECAP Management Company |
900,827 |
0.46 |
-- |
12/31/20 |
| Wells Fargo Advisors |
895,312 |
0.46 |
-58,645 |
12/31/20 |
| Nuveen LLC |
860,912 |
0.44 |
26,609 |
12/31/20 |
| Managed Account Advisors LLC |
756,525 |
0.39 |
-61,406 |
12/31/20 |
| BlackRock Investment Management, LLC |
668,108 |
0.34 |
8,166 |
12/31/20 |
| Morgan Stanley Smith Barney LLC |
623,852 |
0.32 |
-70,727 |
12/31/20 |
| Pura Vida Investments, LLC |
615,286 |
0.32 |
615,286 |
12/31/20 |
| SilverArc Capital Management, LLC |
600,000 |
0.31 |
600,000 |
12/31/20 |
| Voya Investment Management LLC |
577,228 |
0.30 |
517,365 |
12/31/20 |
| BNY Mellon Asset Management |
510,932 |
0.26 |
32,378 |
12/31/20 |
| BlackRock Financial Management, Inc. |
502,334 |
0.26 |
-98,245 |
12/31/20 |
| Enyedy (Mark J) |
429,017 |
0.22 |
-10,000 |
12/22/20 |
| Allianz Global Investors U.S. LLC |
408,265 |
0.21 |
-241,481 |
12/31/20 |
| Schweizerische Nationalbank |
395,300 |
0.20 |
-- |
12/31/20 |
| California Public Employees' Retirement System |
383,709 |
0.20 |
-5,012 |
12/31/20 |
| CM Management, LLC |
375,000 |
0.19 |
375,000 |
12/31/20 |
| Jacobs Levy Equity Management, Inc. |
336,853 |
0.17 |
-48,908 |
12/31/20 |
| PDT Partners, LLC |
330,700 |
0.17 |
-17,600 |
12/31/20 |
| Mellon Investments Corporation |
304,133 |
0.16 |
11,806 |
12/31/20 |
| State of Wisconsin Investment Board |
293,900 |
0.15 |
-71,800 |
12/31/20 |
| Rhumbline Advisers Ltd. Partnership |
291,725 |
0.15 |
32,798 |
12/31/20 |