Investors & Media

Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 296 1,147.70 88.58 176,933,081
Mutual Fund 244 347.10 22.14 44,002,780
Insider 9 7.15 0.52 1,035,668

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 139 330.27 25.35 50,686,905
Sellers 113 -114.47 8.85 -17,692,188
Net 215.80 16.50 32,994,717

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 1,154.85 89.11 177,968,749
Top 10 Inst. 724.26 56.22 112,288,883
Top 20 Inst. 908.21 70.50 140,807,635
Top 50 Inst. 1,072.66 82.97 165,723,898

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 66 47.30 3.57 7,141,240
Aggressive Growth 4 4.36 0.34 675,285
Core Growth 50 39.58 2.98 5,955,962
Growth 12 3.37 0.26 509,993
Income 9 3.42 0.27 536,658
Income Value 2 3.30 0.26 511,742
Yield 7 0.12 0.01 24,916
Index 31 292.99 22.68 45,306,772
Other 89 597.03 46.33 92,533,444
Broker Dealer 26 59.73 4.64 9,259,378
GARP 28 162.28 12.60 25,168,847
Hedge Fund 33 353.67 27.43 54,794,794
Specialty 1 4.88 0.38 756,525
Sector Specific 1 16.47 1.28 2,553,900
Value 38 158.96 12.29 24,553,955
Core Value 32 153.50 11.88 23,734,945
Deep Value 6 5.46 0.41 819,010

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 22,084,103 11.06 -996,025 12/31/20
RA Capital Management, LP 18,417,458 9.22 11,376,973 12/31/20
The Vanguard Group, Inc. 14,157,000 7.09 -31,530 12/31/20
BlackRock Institutional Trust Company, N.A. 13,704,023 6.86 1,433,848 12/31/20
Redmile Group, LLC 10,528,179 5.27 50,300 12/31/20
State Street Global Advisors (US) 8,803,841 4.41 -160,165 12/31/20
Fidelity Institutional Asset Management 8,796,597 4.40 8,706,797 12/31/20
ClearBridge Investments, LLC 6,892,928 3.45 -557,564 12/31/20
Two Sigma Investments, LP 4,668,788 2.34 1,040,528 12/31/20
Renaissance Technologies LLC 4,235,966 2.12 -2,253,173 12/31/20
Morgan Stanley & Co. LLC 4,021,785 2.01 4,006,223 12/31/20
Fidelity Management & Research Company LLC 3,746,017 1.88 2,171,956 12/31/20
Consonance Capital Management LP 3,515,944 1.76 3,515,944 12/31/20
Geode Capital Management, L.L.C. 3,046,603 1.53 275,364 12/31/20
DWS Investments UK Limited 2,787,677 1.40 1,143,153 12/31/20
OrbiMed Advisors, LLC 2,553,900 1.28 2,553,900 12/31/20
Goldman Sachs & Company, Inc. 2,521,843 1.26 1,675,763 12/31/20
Adage Capital Management, L.P. 2,475,000 1.24 2,475,000 12/31/20
Millennium Management LLC 1,953,474 0.98 -2,801,900 12/31/20
Northern Trust Investments, Inc. 1,896,509 0.95 22,797 12/31/20
Compagnie Lombard, Odier SCA 1,849,772 0.93 1,849,772 3/31/21
Columbia Wanger Asset Management, LLC 1,841,000 0.92 427,000 12/31/20
Citadel Advisors LLC 1,734,847 0.87 1,097,928 12/31/20
Marshall Wace LLP 1,574,738 0.79 1,574,738 12/31/20
QVT Financial LP 1,375,900 0.69 -- 12/31/20
PanAgora Asset Management Inc. 1,313,077 0.66 152,565 12/31/20
D. E. Shaw & Co., L.P. 1,255,682 0.63 -385,734 12/31/20
Charles Schwab Investment Management, Inc. 1,227,636 0.61 87,663 12/31/20
Farallon Capital Management, L.L.C. 1,000,000 0.50 1,000,000 12/31/20
Pinnacle Associates Ltd. 975,418 0.49 -65,013 12/31/20
PRIMECAP Management Company 900,827 0.45 -- 12/31/20
Wells Fargo Advisors 895,312 0.45 -58,645 12/31/20
Nuveen LLC 860,912 0.43 26,609 12/31/20
Managed Account Advisors LLC 756,525 0.38 -61,406 12/31/20
BlackRock Investment Management, LLC 668,108 0.33 8,166 12/31/20
Morgan Stanley Smith Barney LLC 623,852 0.31 -70,727 12/31/20
Pura Vida Investments, LLC 615,286 0.31 615,286 12/31/20
SilverArc Capital Management, LLC 600,000 0.30 600,000 12/31/20
Voya Investment Management LLC 577,228 0.29 517,365 12/31/20
BNY Mellon Asset Management 510,932 0.26 32,378 12/31/20
BlackRock Financial Management, Inc. 502,334 0.25 -98,245 12/31/20
Enyedy (Mark J) 429,017 0.21 -- 4/12/21
Allianz Global Investors U.S. LLC 408,265 0.20 -241,481 12/31/20
Schweizerische Nationalbank 395,300 0.20 -- 12/31/20
California Public Employees' Retirement System 383,709 0.19 -5,012 12/31/20
CM Management, LLC 375,000 0.19 375,000 12/31/20
Jacobs Levy Equity Management, Inc. 336,853 0.17 -48,908 12/31/20
PDT Partners, LLC 330,700 0.17 -17,600 12/31/20
Mellon Investments Corporation 304,133 0.15 11,806 12/31/20
State of Wisconsin Investment Board 293,900 0.15 -71,800 12/31/20

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