| RA Capital Management, LP |
21,741,458 |
9.85 |
-- |
6/30/22 |
| State Street Global Advisors (US) |
18,199,554 |
8.25 |
4,492,165 |
6/30/22 |
| The Vanguard Group, Inc. |
16,059,020 |
7.28 |
580,504 |
6/30/22 |
| Deerfield Management Company, L.P. |
15,020,490 |
6.81 |
240,900 |
6/30/22 |
| BlackRock Institutional Trust Company, N.A. |
14,959,232 |
6.78 |
464,766 |
6/30/22 |
| Adage Capital Management, L.P. |
11,586,193 |
5.25 |
-- |
6/30/22 |
| Wellington Management Company, LLP |
10,717,085 |
4.86 |
-2,346,399 |
6/30/22 |
| Redmile Group, LLC |
9,141,045 |
4.14 |
-76,900 |
6/30/22 |
| ClearBridge Investments, LLC |
5,372,065 |
2.43 |
-130,778 |
6/30/22 |
| Millennium Management LLC |
5,057,049 |
2.29 |
1,557,032 |
6/30/22 |
| Two Sigma Investments, LP |
4,852,445 |
2.20 |
304,695 |
6/30/22 |
| Morgan Stanley & Co. LLC |
3,763,494 |
1.71 |
75,952 |
6/30/22 |
| Geode Capital Management, L.L.C. |
3,685,781 |
1.67 |
196,412 |
6/30/22 |
| DWS Investments UK Limited |
2,917,053 |
1.32 |
-14,723 |
6/30/22 |
| Maverick Capital, Ltd. |
2,766,474 |
1.25 |
2,766,474 |
6/30/22 |
| Candriam Luxembourg S.A. |
2,732,557 |
1.24 |
-- |
8/31/22 |
| Norges Bank Investment Management (NBIM) |
1,934,900 |
0.88 |
1,934,900 |
12/31/21 |
| Granahan Investment Management, Inc. |
1,881,796 |
0.85 |
-75,923 |
6/30/22 |
| Citadel Advisors LLC |
1,850,041 |
0.84 |
1,112,373 |
6/30/22 |
| Northern Trust Investments, Inc. |
1,828,503 |
0.83 |
-57,721 |
6/30/22 |
| Dimensional Fund Advisors, L.P. |
1,611,076 |
0.73 |
1,611,076 |
6/30/22 |
| Tang Capital Management, LLC |
1,500,000 |
0.68 |
-- |
6/30/22 |
| Charles Schwab Investment Management, Inc. |
1,464,219 |
0.66 |
-36,000 |
6/30/22 |
| Renaissance Technologies LLC |
1,448,740 |
0.66 |
-13,600 |
6/30/22 |
| Pinnacle Associates Ltd. |
1,390,532 |
0.63 |
-14,136 |
6/30/22 |
| QVT Financial LP |
1,375,900 |
0.62 |
-- |
6/30/22 |
| BlackRock Financial Management, Inc. |
1,333,179 |
0.60 |
544,426 |
6/30/22 |
| Rhenman & Partners Asset Management AB |
1,200,000 |
0.54 |
-225,000 |
6/30/22 |
| PanAgora Asset Management Inc. |
1,161,213 |
0.53 |
-12,642 |
6/30/22 |
| Sofinnova Investments, Inc |
1,140,788 |
0.52 |
-287,381 |
6/30/22 |
| Candriam Belgium S.A. |
1,056,439 |
0.48 |
1,056,439 |
6/30/22 |
| Banque Lombard Odier & Cie SA |
1,004,626 |
0.46 |
-1,270,783 |
6/30/22 |
| Fidelity Management & Research Company LLC |
1,004,083 |
0.45 |
-1,562,939 |
6/30/22 |
| D. E. Shaw & Co., L.P. |
976,927 |
0.44 |
-274,750 |
6/30/22 |
| Nuveen LLC |
958,551 |
0.43 |
-1,231,506 |
6/30/22 |
| Sectoral Asset Management Inc. |
940,244 |
0.43 |
61,400 |
6/30/22 |
| BofA Global Research (US) |
888,491 |
0.40 |
66,301 |
6/30/22 |
| Morgan Stanley Smith Barney LLC |
877,672 |
0.40 |
13,709 |
6/30/22 |
| Segall Bryant & Hamill, LLC |
854,646 |
0.39 |
10,483 |
6/30/22 |
| Citi Investment Research (US) |
803,285 |
0.36 |
619,203 |
6/30/22 |
| Rafferty Asset Management LLC |
748,016 |
0.34 |
-104,868 |
6/30/22 |
| PRIMECAP Management Company |
728,327 |
0.33 |
-28,500 |
6/30/22 |
| BlackRock Advisors (UK) Limited |
720,679 |
0.33 |
7,968 |
9/30/22 |
| FundLogic SAS |
688,051 |
0.31 |
-- |
6/30/22 |
| Goldman Sachs & Company, Inc. |
685,141 |
0.31 |
161,161 |
6/30/22 |
| BlackRock Asset Management Ireland Limited |
681,102 |
0.31 |
440,905 |
6/30/22 |
| Wells Fargo Advisors |
629,852 |
0.29 |
15,416 |
6/30/22 |
| BlackRock Investment Management, LLC |
625,899 |
0.28 |
2,653 |
6/30/22 |
| Managed Account Advisors LLC |
602,973 |
0.27 |
-35,269 |
6/30/22 |
| Medical Strategy GmbH |
539,356 |
0.24 |
-- |
5/31/22 |