Investors & Media

Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 279 1,268.39 87.38 130,217,631
Mutual Fund 256 573.79 39.63 59,059,638
Insider 8 15.89 1.09 1,631,621

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 137 324.00 22.37 33,331,556
Sellers 142 -170.86 11.50 -17,142,531
Net -- 153.14 10.87 16,189,025

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 1,268.39 87.38 130,217,631
Top 10 Inst. 796.40 54.93 81,850,404
Top 20 Inst. 996.33 68.71 102,397,610
Top 50 Inst. 1,175.47 81.00 120,702,969

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 55 79.23 5.47 8,146,595
Aggressive Growth 1 0.05 -- 5,055
Core Growth 41 63.05 4.35 6,482,178
Growth 13 16.12 1.11 1,659,362
Income 10 26.13 1.80 2,685,016
Income Value 4 24.03 1.66 2,469,373
Yield 6 2.11 0.14 215,643
Index 26 329.16 22.70 33,833,318
Other 76 651.33 44.91 66,929,038
Broker Dealer 22 72.37 4.99 7,437,322
GARP 29 306.01 21.10 31,437,930
Hedge Fund 20 116.84 8.06 12,009,153
Sector Specific 2 148.09 10.21 15,220,212
Specialty 3 8.02 0.55 824,421
Value 38 141.67 9.85 14,674,182
Core Value 32 135.82 9.44 14,073,068
Deep Value 6 5.85 0.40 601,114

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Redmile Group, LLC 12,315,942 8.26 2,613,460 6/30/18
The Vanguard Group, Inc. 9,767,517 6.55 878,909 6/30/18
BlackRock Institutional Trust Company, N.A. 9,653,748 6.48 1,847,034 6/30/18
Capital Research Global Investors 9,431,000 6.33 3,923,000 6/30/18
ClearBridge Investments, LLC 9,165,030 6.15 -414,419 6/30/18
State Street Global Advisors (US) 8,996,007 6.04 1,758,759 6/30/18
Fidelity Management & Research Company 8,682,134 5.83 2,186,696 6/30/18
Renaissance Technologies LLC 6,525,300 4.38 1,719,360 6/30/18
PRIMECAP Management Company 3,823,300 2.57 -- 6/30/18
Nuveen LLC 3,490,426 2.34 1,688,540 6/30/18
OrbiMed Advisors, LLC 2,904,270 1.95 1,400,000 6/30/18
T. Rowe Price Associates, Inc. 2,899,111 1.95 689,998 6/30/18
Morgan Stanley & Co. LLC 2,709,638 1.82 1,608,293 6/30/18
Point72 Asset Management, L.P. 2,055,933 1.38 2,055,933 6/30/18
Citadel LLC 1,867,828 1.25 1,415,096 6/30/18
Voya Investment Management LLC 1,849,256 1.24 1,805,412 6/30/18
Franklin Advisers, Inc. 1,737,000 1.17 -935,400 6/30/18
Goldman Sachs & Company, Inc. 1,519,235 1.02 604,541 6/30/18
Geode Capital Management, L.L.C. 1,518,162 1.02 451,768 6/30/18
Northern Trust Investments, Inc. 1,486,773 1.00 346,461 6/30/18
Wells Fargo Advisors 1,382,558 0.93 17,227 6/30/18
Jennison Associates LLC 1,164,643 0.78 1,164,643 6/30/18
Macquarie Investment Management 1,130,000 0.76 -- 6/30/18
Pinnacle Associates Ltd. 1,096,937 0.74 -170,570 6/30/18
Capital World Investors 950,000 0.64 950,000 6/30/18
Enyedy (Mark J) 921,383 0.62 389,000 4/23/18
PanAgora Asset Management Inc. 903,307 0.61 49,607 6/30/18
Candriam Belgium S.A. 842,000 0.57 148,000 7/31/18
Managed Account Advisors LLC 822,221 0.55 -66,859 6/30/18
Morgan Stanley Wealth Management 813,555 0.55 -18,564 6/30/18
Charles Schwab Investment Management, Inc. 765,956 0.51 234,880 6/30/18
Allianz Global Investors U.S. LLC 760,787 0.51 386,834 6/30/18
Candriam Luxembourg S.A. 694,000 0.47 100,000 6/30/18
Raymond James & Associates, Inc. 648,758 0.44 23,459 6/30/18
Chicago Equity Partners, LLC 526,660 0.35 22,895 6/30/18
BlackRock Investment Management, LLC 406,822 0.27 70,435 6/30/18
Bank of America Merrill Lynch (US) 391,000 0.26 283,279 6/30/18
Gregory (Richard J) 386,844 0.26 147,753 4/23/18
First Trust Advisors L.P. 369,528 0.25 369,528 6/30/18
Medical Strategy GmbH 355,870 0.24 -37,000 5/31/18
BNY Mellon Asset Management 338,156 0.23 51,393 6/30/18
Norges Bank Investment Management (NBIM) 333,979 0.22 -- 12/31/17
Two Sigma Investments, LP 317,634 0.21 -590,034 6/30/18
Johnston David Brannon 303,940 0.20 123,250 6/6/18
Granahan Investment Management, Inc. 302,000 0.20 -- 3/31/18
Wells Fargo Bank, N.A. 300,708 0.20 -44,777 6/30/18
Monashee Investment Management, LLC 275,000 0.18 275,000 6/30/18
Deutsche Asset Management Americas 272,532 0.18 -353,823 6/30/18
BlackRock Financial Management, Inc. 271,377 0.18 151,137 6/30/18
Millennium Management LLC 257,204 0.17 -1,373,778 6/30/18

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