| Redmile Group, LLC |
12,315,942 |
8.26 |
2,613,460 |
6/30/18 |
| The Vanguard Group, Inc. |
9,767,517 |
6.55 |
878,909 |
6/30/18 |
| BlackRock Institutional Trust Company, N.A. |
9,653,748 |
6.48 |
1,847,034 |
6/30/18 |
| Capital Research Global Investors |
9,431,000 |
6.33 |
3,923,000 |
6/30/18 |
| ClearBridge Investments, LLC |
9,165,030 |
6.15 |
-414,419 |
6/30/18 |
| State Street Global Advisors (US) |
8,996,007 |
6.04 |
1,758,759 |
6/30/18 |
| Fidelity Management & Research Company |
8,682,134 |
5.83 |
2,186,696 |
6/30/18 |
| Renaissance Technologies LLC |
6,525,300 |
4.38 |
1,719,360 |
6/30/18 |
| PRIMECAP Management Company |
3,823,300 |
2.57 |
-- |
6/30/18 |
| Nuveen LLC |
3,490,426 |
2.34 |
1,688,540 |
6/30/18 |
| OrbiMed Advisors, LLC |
2,904,270 |
1.95 |
1,400,000 |
6/30/18 |
| T. Rowe Price Associates, Inc. |
2,899,111 |
1.95 |
689,998 |
6/30/18 |
| Morgan Stanley & Co. LLC |
2,709,638 |
1.82 |
1,608,293 |
6/30/18 |
| Point72 Asset Management, L.P. |
2,055,933 |
1.38 |
2,055,933 |
6/30/18 |
| Citadel LLC |
1,867,828 |
1.25 |
1,415,096 |
6/30/18 |
| Voya Investment Management LLC |
1,849,256 |
1.24 |
1,805,412 |
6/30/18 |
| Franklin Advisers, Inc. |
1,737,000 |
1.17 |
-935,400 |
6/30/18 |
| Goldman Sachs & Company, Inc. |
1,519,235 |
1.02 |
604,541 |
6/30/18 |
| Geode Capital Management, L.L.C. |
1,518,162 |
1.02 |
451,768 |
6/30/18 |
| Northern Trust Investments, Inc. |
1,489,838 |
1.00 |
349,526 |
6/30/18 |
| Wells Fargo Advisors |
1,382,558 |
0.93 |
17,227 |
6/30/18 |
| Jennison Associates LLC |
1,164,643 |
0.78 |
1,164,643 |
6/30/18 |
| Macquarie Investment Management |
1,130,000 |
0.76 |
-- |
6/30/18 |
| Pinnacle Associates Ltd. |
1,096,937 |
0.74 |
-170,570 |
6/30/18 |
| Capital World Investors |
950,000 |
0.64 |
950,000 |
6/30/18 |
| Enyedy (Mark J) |
921,383 |
0.62 |
389,000 |
4/23/18 |
| PanAgora Asset Management Inc. |
903,307 |
0.61 |
49,607 |
6/30/18 |
| Managed Account Advisors LLC |
822,221 |
0.55 |
-66,859 |
6/30/18 |
| Morgan Stanley Wealth Management |
813,555 |
0.55 |
-18,564 |
6/30/18 |
| Charles Schwab Investment Management, Inc. |
765,956 |
0.51 |
234,880 |
6/30/18 |
| Allianz Global Investors U.S. LLC |
760,787 |
0.51 |
386,834 |
6/30/18 |
| Candriam Belgium S.A. |
694,000 |
0.47 |
100,000 |
6/30/18 |
| Candriam Luxembourg S.A. |
694,000 |
0.47 |
100,000 |
6/30/18 |
| Raymond James & Associates, Inc. |
648,758 |
0.44 |
23,459 |
6/30/18 |
| Chicago Equity Partners, LLC |
526,660 |
0.35 |
22,895 |
6/30/18 |
| BlackRock Investment Management, LLC |
406,822 |
0.27 |
70,435 |
6/30/18 |
| Bank of America Merrill Lynch (US) |
391,000 |
0.26 |
283,279 |
6/30/18 |
| Gregory (Richard J) |
386,844 |
0.26 |
147,753 |
4/23/18 |
| First Trust Advisors L.P. |
369,528 |
0.25 |
369,528 |
6/30/18 |
| Medical Strategy GmbH |
355,870 |
0.24 |
-37,000 |
5/31/18 |
| BNY Mellon Asset Management |
338,156 |
0.23 |
51,393 |
6/30/18 |
| Norges Bank Investment Management (NBIM) |
333,979 |
0.22 |
-- |
12/31/17 |
| Two Sigma Investments, LP |
317,634 |
0.21 |
-590,034 |
6/30/18 |
| Johnston David Brannon |
313,940 |
0.21 |
133,250 |
6/6/18 |
| Granahan Investment Management, Inc. |
302,000 |
0.20 |
-- |
3/31/18 |
| Wells Fargo Bank, N.A. |
300,708 |
0.20 |
-44,777 |
6/30/18 |
| Monashee Investment Management, LLC |
275,000 |
0.18 |
275,000 |
6/30/18 |
| Deutsche Asset Management Americas |
272,532 |
0.18 |
-353,823 |
6/30/18 |
| BlackRock Financial Management, Inc. |
271,377 |
0.18 |
151,137 |
6/30/18 |
| INVESCO Asset Management Deutschland GmbH |
267,750 |
0.18 |
-2,800 |
3/31/18 |