Investors & Media

Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 279 662.25 87.84 130,962,883
Mutual Fund 238 265.18 35.26 52,572,175
Insider 10 10.53 1.13 1,692,068

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 128 101.42 13.79 20,564,746
Sellers 150 -130.69 15.50 -23,108,430
Net -- -29.28 1.71 -2,543,684

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 662.25 87.84 130,962,883
Top 10 Inst. 353.52 49.40 73,650,669
Top 20 Inst. 480.90 64.82 96,637,570
Top 50 Inst. 599.48 80.12 119,451,640

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 54 57.21 6.98 10,405,507
Aggressive Growth 3 2.20 0.31 458,484
Core Growth 38 41.63 5.25 7,826,863
Growth 13 13.38 1.42 2,120,160
Income 9 3.71 0.52 770,725
Income Value 3 1.93 0.27 401,134
Yield 6 1.78 0.25 369,591
Index 26 169.38 23.63 35,237,018
Other 87 369.61 49.22 73,387,157
Broker Dealer 22 41.38 5.77 8,609,075
GARP 30 167.20 20.96 31,246,747
Hedge Fund 31 101.85 14.22 21,203,697
Sector Specific 1 52.25 7.30 10,884,607
Specialty 1 3.59 0.50 747,207
VC/Private Equi 2 3.34 0.47 695,824
Value 32 32.67 4.06 6,056,312
Core Value 24 11.37 1.14 1,696,310
Deep Value 8 21.30 2.92 4,360,002

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Redmile Group, LLC 10,884,607 7.30 -1,424,428 12/31/18
BlackRock Institutional Trust Company, N.A. 10,562,920 7.08 -91,311 12/31/18
The Vanguard Group, Inc. 10,492,223 7.04 333,789 12/31/18
ClearBridge Investments, LLC 8,406,481 5.64 322,630 12/31/18
State Street Global Advisors (US) 8,100,371 5.43 -831,141 12/31/18
Fidelity Management & Research Company 6,407,584 4.30 -1,069,613 12/31/18
Renaissance Technologies LLC 6,182,140 4.15 -130,500 12/31/18
Morgan Stanley & Co. LLC 4,460,083 2.99 2,466,675 12/31/18
Millennium Management LLC 4,389,260 2.94 3,552,118 12/31/18
PRIMECAP Management Company 3,765,000 2.53 -23,800 12/31/18
Nuveen LLC 3,647,973 2.45 157,547 9/30/18
ArrowMark Colorado Holdings, LLC 3,606,724 2.42 1,678,774 12/31/18
Point72 Asset Management, L.P. 2,654,299 1.78 -3,518,466 12/31/18
Citadel LLC 2,620,704 1.76 315,028 12/31/18
T. Rowe Price Associates, Inc. 2,337,293 1.57 66,546 12/31/18
Voya Investment Management LLC 2,232,721 1.50 -191,296 12/31/18
Geode Capital Management, L.L.C. 1,717,770 1.15 96,984 12/31/18
Northern Trust Investments, Inc. 1,661,789 1.11 -15,194 12/31/18
Two Sigma Investments, LP 1,313,397 0.88 1,181,392 12/31/18
Deutsche Asset Management Americas 1,194,231 0.80 760,336 12/31/18
Wells Fargo Advisors 1,154,913 0.77 -138,162 12/31/18
BlackRock Financial Management, Inc. 1,136,245 0.76 871,505 12/31/18
Goldman Sachs & Company, Inc. 1,104,132 0.74 -155,674 12/31/18
PanAgora Asset Management Inc. 1,101,037 0.74 164,249 12/31/18
Susquehanna International Group, LLP 1,075,297 0.72 1,075,297 12/31/18
Jennison Associates LLC 1,072,821 0.72 -100,539 12/31/18
BNP Paribas Asset Management USA, Inc. 1,038,616 0.70 100,781 12/31/18
Candriam Luxembourg S.A. 1,021,139 0.68 68,639 12/31/18
Opaleye Management Inc. 1,021,000 0.68 1,021,000 12/31/18
Candriam Belgium S.A. 1,012,500 0.68 60,000 12/31/18
J. Goldman & Co., L.P. 1,004,876 0.67 708,763 12/31/18
Enyedy (Mark J) 923,838 0.62 2,455 1/3/19
Pinnacle Associates Ltd. 908,776 0.61 -33,404 12/31/18
Charles Schwab Investment Management, Inc. 843,417 0.57 -28,420 12/31/18
Morgan Stanley Wealth Management 809,299 0.54 -4,256 9/30/18
Morgan Stanley Investment Management Inc. (US) 774,189 0.52 771,106 12/31/18
Managed Account Advisors LLC 747,207 0.50 -52,713 12/31/18
Macquarie Investment Management 650,000 0.44 -480,000 9/30/18
BNP Paribas Asset Management UK Limited 624,606 0.42 -12,785 12/31/18
Raymond James & Associates, Inc. 595,549 0.40 -53,284 12/31/18
Citi Investment Research (US) 522,709 0.35 417,739 12/31/18
BlackRock Investment Management, LLC 520,566 0.35 71,546 12/31/18
Sofinnova Ventures, Inc. 447,075 0.30 447,075 12/31/18
Medical Strategy GmbH 429,870 0.29 77,500 12/31/18
OxFORD Asset Management 413,953 0.28 413,953 12/31/18
California Public Employees' Retirement System 383,986 0.26 199,455 12/31/18
Gregory (Richard J) 383,806 0.26 -3,038 1/7/19
BNY Mellon Asset Management 382,639 0.26 -10,335 12/31/18
Numeric Investors LLC 359,200 0.24 351,900 9/30/18
UBS Financial Services, Inc. 350,809 0.24 184,822 12/31/18

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