Investors & Media

Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 277 621.57 86.30 128,947,767
Mutual Fund 227 239.86 38.35 57,296,923
Insider 10 10.68 1.13 1,692,068

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 132 95.21 13.52 20,204,662
Sellers 127 -100.31 13.99 -20,899,287
Net -- -5.10 0.47 -694,625

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 621.57 86.30 128,947,767
Top 10 Inst. 353.52 49.29 73,650,669
Top 20 Inst. 456.01 63.58 95,002,116
Top 50 Inst. 565.04 78.86 117,817,696

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 55 52.12 7.46 11,144,366
Aggressive Growth 4 3.03 0.42 631,331
Core Growth 39 37.86 5.28 7,887,711
Growth 12 11.23 1.76 2,625,324
Income 11 3.66 0.52 771,680
Income Value 4 1.93 0.27 402,022
Yield 7 1.73 0.25 369,658
Index 25 168.25 23.47 35,062,480
Other 87 341.24 47.57 71,073,859
Broker Dealer 22 41.16 5.74 8,575,866
GARP 30 138.63 19.26 28,779,947
Hedge Fund 30 101.76 14.19 21,197,509
Sector Specific 1 52.25 7.29 10,884,607
Specialty 2 4.11 0.63 940,106
VC/Private Equi 2 3.34 0.47 695,824
Value 30 29.10 4.05 6,055,533
Core Value 23 8.55 1.19 1,774,617
Deep Value 7 20.55 2.87 4,280,916

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Redmile Group, LLC 10,884,607 7.29 -1,424,428 12/31/18
BlackRock Institutional Trust Company, N.A. 10,562,920 7.07 -91,311 12/31/18
The Vanguard Group, Inc. 10,492,223 7.02 333,789 12/31/18
ClearBridge Investments, LLC 8,406,481 5.63 322,630 12/31/18
State Street Global Advisors (US) 8,100,371 5.42 -831,141 12/31/18
Fidelity Management & Research Company 6,407,584 4.29 -1,069,613 12/31/18
Renaissance Technologies LLC 6,182,140 4.14 -130,500 12/31/18
Morgan Stanley & Co. LLC 4,460,083 2.99 2,466,675 12/31/18
Millennium Management LLC 4,389,260 2.94 3,552,118 12/31/18
PRIMECAP Management Company 3,765,000 2.52 -23,800 12/31/18
ArrowMark Colorado Holdings, LLC 3,606,724 2.41 1,678,774 12/31/18
Point72 Asset Management, L.P. 2,654,299 1.78 -3,518,466 12/31/18
Citadel LLC 2,620,704 1.75 315,028 12/31/18
T. Rowe Price Associates, Inc. 2,337,293 1.56 66,546 12/31/18
Voya Investment Management LLC 2,232,721 1.49 -191,296 12/31/18
Nuveen LLC 2,012,519 1.35 -1,635,454 12/31/18
Geode Capital Management, L.L.C. 1,717,770 1.15 96,984 12/31/18
Northern Trust Investments, Inc. 1,661,789 1.11 -15,194 12/31/18
Two Sigma Investments, LP 1,313,397 0.88 1,181,392 12/31/18
Deutsche Asset Management Americas 1,194,231 0.80 760,336 12/31/18
Wells Fargo Advisors 1,154,913 0.77 -138,162 12/31/18
BlackRock Financial Management, Inc. 1,136,245 0.76 871,505 12/31/18
Goldman Sachs & Company, Inc. 1,104,132 0.74 -155,674 12/31/18
PanAgora Asset Management Inc. 1,101,037 0.74 164,249 12/31/18
Susquehanna International Group, LLP 1,075,297 0.72 1,075,297 12/31/18
Jennison Associates LLC 1,072,821 0.72 -100,539 12/31/18
BNP Paribas Asset Management USA, Inc. 1,038,616 0.70 100,781 12/31/18
Candriam Belgium S.A. 1,027,595 0.69 15,095 1/31/19
Candriam Luxembourg S.A. 1,021,139 0.68 68,639 12/31/18
Opaleye Management Inc. 1,021,000 0.68 1,021,000 12/31/18
J. Goldman & Co., L.P. 1,004,876 0.67 708,763 12/31/18
Enyedy (Mark J) 923,838 0.62 2,455 1/3/19
Pinnacle Associates Ltd. 908,776 0.61 -33,404 12/31/18
Charles Schwab Investment Management, Inc. 843,417 0.56 -28,420 12/31/18
Morgan Stanley Smith Barney LLC 773,789 0.52 -35,510 12/31/18
Managed Account Advisors LLC 747,207 0.50 -52,713 12/31/18
Rafferty Asset Management LLC 697,625 0.47 697,625 3/31/19
Macquarie Investment Management 650,000 0.44 -- 12/31/18
BNP Paribas Asset Management UK Limited 625,684 0.42 1,078 2/28/19
Raymond James & Associates, Inc. 595,549 0.40 -53,284 12/31/18
Citi Investment Research (US) 522,709 0.35 417,739 12/31/18
BlackRock Investment Management, LLC 520,566 0.35 71,546 12/31/18
Numeric Investors LLC 450,555 0.30 91,355 12/31/18
Sofinnova Ventures, Inc. 447,075 0.30 447,075 12/31/18
Norges Bank Investment Management (NBIM) 428,383 0.29 94,404 12/31/18
OxFORD Asset Management 413,953 0.28 413,953 12/31/18
California Public Employees' Retirement System 383,986 0.26 199,455 12/31/18
Gregory (Richard J) 383,806 0.26 -3,038 1/7/19
BNY Mellon Asset Management 382,639 0.26 -10,335 12/31/18
Medical Strategy GmbH 358,352 0.24 -71,518 2/28/19

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