The Vanguard Group, Inc. |
25,418,388 |
9.10 |
979,857 |
12/31/23 |
RA Capital Management, LP |
23,750,601 |
8.50 |
10,428,313 |
12/31/23 |
BlackRock Institutional Trust Company, N.A. |
18,646,679 |
6.67 |
1,793,786 |
12/31/23 |
Redmile Group, LLC |
16,423,922 |
5.88 |
-1,079,495 |
12/31/23 |
Janus Henderson Investors |
11,043,986 |
3.95 |
-6,640,830 |
12/31/23 |
State Street Global Advisors (US) |
8,075,671 |
2.89 |
-1,476,181 |
12/31/23 |
Fairmount Funds Management LLC |
5,929,592 |
2.12 |
-- |
12/31/23 |
Pentwater Capital Management LP |
5,662,500 |
2.03 |
5,662,500 |
12/31/23 |
Norges Bank Investment Management (NBIM) |
5,539,334 |
1.98 |
5,424,434 |
12/31/23 |
Geode Capital Management, L.L.C. |
5,382,875 |
1.93 |
482,900 |
12/31/23 |
Fidelity Investments Canada ULC |
5,360,000 |
1.92 |
5,360,000 |
12/31/23 |
D. E. Shaw & Co., L.P. |
4,522,797 |
1.62 |
-2,472,442 |
12/31/23 |
Millennium Management LLC |
4,473,868 |
1.60 |
2,868,154 |
12/31/23 |
Voloridge Investment Management, LLC |
3,221,231 |
1.15 |
708,980 |
12/31/23 |
Boxer Capital, L.L.C. |
2,961,000 |
1.06 |
-- |
12/31/23 |
Emerald Advisers LLC |
2,933,190 |
1.05 |
-344,179 |
12/31/23 |
Maverick Capital, Ltd. |
2,493,217 |
0.89 |
-25,310 |
12/31/23 |
TIG Advisors, L.L.C. |
2,313,670 |
0.83 |
2,313,670 |
12/31/23 |
Morgan Stanley & Co. LLC |
2,209,536 |
0.79 |
64,583 |
12/31/23 |
Tang Capital Management, LLC |
2,199,137 |
0.79 |
699,137 |
12/31/23 |
Northern Trust Investments, Inc. |
2,072,998 |
0.74 |
62,196 |
12/31/23 |
Nuveen LLC |
2,041,214 |
0.73 |
-845,027 |
12/31/23 |
Kryger Capital Limited |
2,036,155 |
0.73 |
2,036,155 |
12/31/23 |
Wellington Management Company, LLP |
1,954,413 |
0.70 |
-11,304,584 |
12/31/23 |
Medical Strategy GmbH |
1,910,763 |
0.68 |
-216,000 |
12/31/23 |
Charles Schwab Investment Management, Inc. |
1,892,446 |
0.68 |
61,871 |
12/31/23 |
Avidity Partners Management LP |
1,829,215 |
0.65 |
-88,692 |
12/31/23 |
HOOPP Investment Management |
1,785,296 |
0.64 |
1,485,296 |
12/31/23 |
Alpine Associates Management Inc. |
1,761,300 |
0.63 |
1,749,300 |
12/31/23 |
Renaissance Technologies LLC |
1,631,240 |
0.58 |
896,600 |
12/31/23 |
Magnetar Capital Partners LP |
1,629,285 |
0.58 |
1,629,285 |
12/31/23 |
Sofinnova Investments, Inc |
1,546,902 |
0.55 |
-498,300 |
12/31/23 |
AllianceBernstein L.P. |
1,507,809 |
0.54 |
1,207,295 |
12/31/23 |
AQR Capital Management, LLC |
1,506,601 |
0.54 |
1,380,964 |
12/31/23 |
Balyasny Asset Management LP |
1,496,758 |
0.54 |
1,484,838 |
12/31/23 |
Morgan Stanley Investment Management Inc. (US) |
1,487,210 |
0.53 |
-544,787 |
12/31/23 |
Gabelli Funds, LLC |
1,422,804 |
0.51 |
1,422,804 |
12/31/23 |
Kynam Capital Management LP |
1,422,503 |
0.51 |
1,422,503 |
12/31/23 |
Affinity Asset Advisors LLC |
1,404,608 |
0.50 |
1,404,608 |
12/31/23 |
QVT Financial LP |
1,375,900 |
0.49 |
-- |
12/31/23 |
Westchester Capital Management, LLC |
1,364,927 |
0.49 |
1,364,927 |
12/31/23 |
J.P. Morgan Securities LLC |
1,265,347 |
0.45 |
28,617 |
12/31/23 |
BlackRock Financial Management, Inc. |
1,243,147 |
0.45 |
-259,980 |
12/31/23 |
Marshall Wace LLP |
1,187,027 |
0.42 |
1,187,027 |
12/31/23 |
Artisan Partners Limited Partnership |
1,172,323 |
0.42 |
-2,552,260 |
12/31/23 |
Principal Global Investors (Equity) |
1,127,402 |
0.40 |
142,738 |
12/31/23 |
Candriam Belgium S.A. |
1,122,598 |
0.40 |
10 |
12/31/23 |
Pictet Asset Management Ltd. |
975,962 |
0.35 |
-2,732,177 |
12/31/23 |
Adage Capital Management, L.P. |
971,928 |
0.35 |
771,928 |
12/31/23 |
T. Rowe Price Associates, Inc. |
963,620 |
0.34 |
-2,811,554 |
12/31/23 |