Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 270 709.43 81.46 108,220,962
Mutual Fund 220 425.25 36.43 48,399,856
Insider 11 15.52 1.39 1,843,792

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 153 151.68 17.60 23,381,315
Sellers 97 -65.69 7.67 -10,189,373
Net -- 85.98 9.93 13,191,942

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 709.43 81.46 108,220,962
Top 10 Inst. 423.56 49.74 66,077,531
Top 20 Inst. 521.50 61.24 81,357,868
Top 50 Inst. 640.23 74.15 98,507,539

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 53 31.56 3.71 4,930,923
Aggressive Growth 2 1.09 0.07 98,050
Core Growth 39 27.33 3.27 4,345,749
Growth 12 3.14 0.37 487,124
Income 11 22.65 2.64 3,506,170
Income Value 5 21.52 2.52 3,341,377
Yield 6 1.12 0.12 164,793
Index 24 197.26 23.14 30,746,418
Other 73 391.25 45.34 60,236,886
Broker Dealer 18 37.94 4.42 5,867,987
GARP 24 181.97 20.81 27,639,590
Hedge Fund 26 77.05 9.05 12,019,244
Sector Specific 2 88.08 10.34 13,741,088
Specialty 3 6.22 0.73 968,977
Value 35 33.44 3.66 4,858,848
Core Value 27 30.59 3.33 4,418,233
Deep Value 8 2.86 0.33 440,615

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
ClearBridge Investments, LLC 11,071,365 8.33 -374,246 12/31/17
Redmile Group, LLC 10,906,962 8.21 2,845,465 12/31/17
The Vanguard Group, Inc. 9,655,527 7.27 2,376,273 12/31/17
State Street Global Advisors (US) 8,345,171 6.28 2,167,366 12/31/17
BlackRock Institutional Trust Company, N.A. 7,887,708 5.94 2,882,942 12/31/17
Fidelity Management & Research Company 5,605,285 4.22 -- 12/31/17
PRIMECAP Management Company 3,823,300 2.88 -- 12/31/17
Franklin Advisers, Inc. 3,006,600 2.26 195,700 12/31/17
Millennium Management LLC 2,941,487 2.21 -845,940 12/31/17
OrbiMed Advisors, LLC 2,834,126 2.13 -2,616,455 12/31/17
Baker Bros. Advisors LP 2,563,489 1.93 -125,000 12/31/17
T. Rowe Price Associates, Inc. 1,975,716 1.49 1,040,580 12/31/17
Nuveen LLC 1,911,430 1.44 579,742 12/31/17
Two Sigma Investments, LP 1,613,641 1.21 1,203,932 12/31/17
Wells Fargo Advisors 1,404,958 1.06 -9,346 12/31/17
Pinnacle Associates Ltd. 1,322,231 1.00 -144,448 12/31/17
Morgan Stanley & Co. International Plc 1,142,300 0.86 1,142,300 12/31/17
Macquarie Investment Management 1,130,000 0.85 280,000 12/31/17
Northern Trust Investments, Inc. 1,123,332 0.85 133,480 12/31/17
Renaissance Technologies LLC 1,093,240 0.82 568,900 12/31/17
Invesco PowerShares Capital Management LLC 1,058,198 0.80 583,800 12/31/17
FundLogic SAS 997,645 0.75 997,645 12/31/17
Managed Account Advisors LLC 966,636 0.73 -722,748 12/31/17
Geode Capital Management, L.L.C. 955,193 0.72 70,643 12/31/17
Morgan Stanley & Co. LLC 897,518 0.68 782,939 12/31/17
Schonfeld Strategic Advisors LLC 865,356 0.65 -93,489 12/31/17
Morgan Stanley Wealth Management 856,665 0.64 -14,683 12/31/17
PanAgora Asset Management Inc. 714,067 0.54 -205,442 12/31/17
Deutsche Asset Management Americas 647,381 0.49 60,694 12/31/17
Raymond James & Associates, Inc. 619,357 0.47 161,603 12/31/17
Candriam Luxembourg S.A. 570,000 0.43 -- 12/31/17
Invesco Advisers, Inc. 552,680 0.42 77,790 12/31/17
Candriam Belgium S.A. 535,000 0.40 -35,000 2/28/18
Enyedy (Mark J) 532,383 0.40 -67,717 2/21/18
Charles Schwab Investment Management, Inc. 522,964 0.39 81,519 12/31/17
Sphera Funds Management Ltd. 500,000 0.38 500,000 12/31/17
Chicago Equity Partners, LLC 489,035 0.37 -1,600 12/31/17
Medical Strategy GmbH 488,370 0.37 -6,000 2/28/18
Citi Investment Research (US) 450,435 0.34 207,007 12/31/17
J.P. Morgan Securities LLC 410,001 0.31 410,001 12/31/17
Hauck & Aufhäuser Asset Management Services S.à r.l. 409,862 0.31 -- 9/30/17
Fisher Investments 408,304 0.31 249,828 3/31/18
Wellington Management Company, LLP 406,661 0.31 94,898 12/31/17
AQR Capital Management, LLC 394,957 0.30 333,455 12/31/17
Jacobs Levy Equity Management, Inc. 352,524 0.27 15,500 12/31/17
BlackRock Investment Management, LLC 351,127 0.26 53,039 12/31/17
Norges Bank Investment Management (NBIM) 333,979 0.25 -1,196,793 12/31/17
Granahan Investment Management, Inc. 302,000 0.23 -302,000 12/31/17
BNY Mellon Asset Management 286,206 0.22 36,353 12/31/17
APG Asset Management 275,167 0.21 34,867 3/31/17

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