Redmile Group, LLC |
10,884,607 |
7.30 |
-1,424,428 |
12/31/18 |
BlackRock Institutional Trust Company, N.A. |
10,562,920 |
7.08 |
-91,311 |
12/31/18 |
The Vanguard Group, Inc. |
10,492,223 |
7.04 |
333,789 |
12/31/18 |
ClearBridge Investments, LLC |
8,406,481 |
5.64 |
322,630 |
12/31/18 |
State Street Global Advisors (US) |
8,100,371 |
5.43 |
-831,141 |
12/31/18 |
Fidelity Management & Research Company |
6,407,584 |
4.30 |
-1,069,613 |
12/31/18 |
Renaissance Technologies LLC |
6,182,140 |
4.15 |
-130,500 |
12/31/18 |
Morgan Stanley & Co. LLC |
4,460,083 |
2.99 |
2,466,675 |
12/31/18 |
Millennium Management LLC |
4,389,260 |
2.94 |
3,552,118 |
12/31/18 |
PRIMECAP Management Company |
3,765,000 |
2.53 |
-23,800 |
12/31/18 |
Nuveen LLC |
3,647,973 |
2.45 |
157,547 |
9/30/18 |
ArrowMark Colorado Holdings, LLC |
3,606,724 |
2.42 |
1,678,774 |
12/31/18 |
Point72 Asset Management, L.P. |
2,654,299 |
1.78 |
-3,518,466 |
12/31/18 |
Citadel LLC |
2,620,704 |
1.76 |
315,028 |
12/31/18 |
T. Rowe Price Associates, Inc. |
2,337,293 |
1.57 |
66,546 |
12/31/18 |
Voya Investment Management LLC |
2,232,721 |
1.50 |
-191,296 |
12/31/18 |
Geode Capital Management, L.L.C. |
1,717,770 |
1.15 |
96,984 |
12/31/18 |
Northern Trust Investments, Inc. |
1,661,789 |
1.11 |
-15,194 |
12/31/18 |
Two Sigma Investments, LP |
1,313,397 |
0.88 |
1,181,392 |
12/31/18 |
Deutsche Asset Management Americas |
1,194,231 |
0.80 |
760,336 |
12/31/18 |
Wells Fargo Advisors |
1,154,913 |
0.77 |
-138,162 |
12/31/18 |
BlackRock Financial Management, Inc. |
1,136,245 |
0.76 |
871,505 |
12/31/18 |
Goldman Sachs & Company, Inc. |
1,104,132 |
0.74 |
-155,674 |
12/31/18 |
PanAgora Asset Management Inc. |
1,101,037 |
0.74 |
164,249 |
12/31/18 |
Susquehanna International Group, LLP |
1,075,297 |
0.72 |
1,075,297 |
12/31/18 |
Jennison Associates LLC |
1,072,821 |
0.72 |
-100,539 |
12/31/18 |
BNP Paribas Asset Management USA, Inc. |
1,038,616 |
0.70 |
100,781 |
12/31/18 |
Candriam Luxembourg S.A. |
1,021,139 |
0.68 |
68,639 |
12/31/18 |
Opaleye Management Inc. |
1,021,000 |
0.68 |
1,021,000 |
12/31/18 |
Candriam Belgium S.A. |
1,012,500 |
0.68 |
60,000 |
12/31/18 |
J. Goldman & Co., L.P. |
1,004,876 |
0.67 |
708,763 |
12/31/18 |
Enyedy (Mark J) |
923,838 |
0.62 |
2,455 |
1/3/19 |
Pinnacle Associates Ltd. |
908,776 |
0.61 |
-33,404 |
12/31/18 |
Charles Schwab Investment Management, Inc. |
843,417 |
0.57 |
-28,420 |
12/31/18 |
Morgan Stanley Wealth Management |
809,299 |
0.54 |
-4,256 |
9/30/18 |
Morgan Stanley Investment Management Inc. (US) |
774,189 |
0.52 |
771,106 |
12/31/18 |
Managed Account Advisors LLC |
747,207 |
0.50 |
-52,713 |
12/31/18 |
Macquarie Investment Management |
650,000 |
0.44 |
-480,000 |
9/30/18 |
BNP Paribas Asset Management UK Limited |
624,606 |
0.42 |
-12,785 |
12/31/18 |
Raymond James & Associates, Inc. |
595,549 |
0.40 |
-53,284 |
12/31/18 |
Citi Investment Research (US) |
522,709 |
0.35 |
417,739 |
12/31/18 |
BlackRock Investment Management, LLC |
520,566 |
0.35 |
71,546 |
12/31/18 |
Sofinnova Ventures, Inc. |
447,075 |
0.30 |
447,075 |
12/31/18 |
Medical Strategy GmbH |
429,870 |
0.29 |
77,500 |
12/31/18 |
OxFORD Asset Management |
413,953 |
0.28 |
413,953 |
12/31/18 |
California Public Employees' Retirement System |
383,986 |
0.26 |
199,455 |
12/31/18 |
Gregory (Richard J) |
383,806 |
0.26 |
-3,038 |
1/7/19 |
BNY Mellon Asset Management |
382,639 |
0.26 |
-10,335 |
12/31/18 |
Numeric Investors LLC |
359,200 |
0.24 |
351,900 |
9/30/18 |
UBS Financial Services, Inc. |
350,809 |
0.24 |
184,822 |
12/31/18 |