ImmunoGen, Inc.
Jun 3, 2012

ImmunoGen, Inc. Announces Results from Trastuzumab Emtansine (T-DM1) EMILIA Phase III Trial

WALTHAM, Mass.--(BUSINESS WIRE)-- ImmunoGen, Inc. (Nasdaq: IMGN), a biotechnology company with a proprietary Targeted Antibody Payload (TAP) technology, today announced results from the trastuzumab emtansine Phase III EMILIA trial conducted by Roche. Trastuzumab emtansine comprises ImmunoGen's DM1 cancer cell-killing agent linked to the trastuzumab antibody developed by Genentech, a member of the Roche Group, using ImmunoGen's method of attachment. It is in global development by Roche under an agreement between ImmunoGen and Genentech. Roche plans to apply this year for marketing approval of trastuzumab emtansine in the US and Europe using EMILIA data.

The EMILIA 991-patient trial compares trastuzumab emtansine, used alone, to lapatinib (Tykerb®) plus capecitabine (Xeloda®) for the treatment of HER2-positive metastatic breast cancer that has progressed after treatment with trastuzumab (Herceptin®) and a taxane in any setting (early or metastatic disease).

Among the study findings reported are:

The EMILIA data have been selected for presentation in a plenary session of the American Society of Clinical Oncology (ASCO) annual meeting this afternoon (Abstract #LBA1) and were also featured in the official ASCO press program.

"These results show that trastuzumab emtansine can make a notable difference for patients and their families," commented Daniel Junius, President and CEO. "We developed our TAP technology to achieve markedly better anticancer therapies and believe these data validate our approach. We look forward to Roche applying for marketing approval of trastuzumab emtansine."

In addition to EMILIA, trastuzumab emtansine is in Phase III testing for treatment of HER2-positive metastatic breast cancer in the MARIANNE and TH3RESA trials.

About ImmunoGen's Targeted Antibody Payload (TAP) Technology

ImmunoGen developed its TAP technology to achieve more effective, better tolerated anticancer drugs. A TAP compound consists of a manufactured antibody that binds specifically to a target found on tumor cells with one of the Company's highly potent cancer cell-killing agents attached as a payload using one of ImmunoGen's engineered linkers. The antibody serves to target the payload specifically to the cancer cells and the payload serves to kill the cancer cells. In some compounds, the antibody component also has meaningful anticancer activity.

About ImmunoGen, Inc.

ImmunoGen, Inc. develops targeted anticancer therapeutics using the Company's expertise in tumor biology, monoclonal antibodies, potent cancer-cell killing agents and engineered linkers. The Company's TAP technology uses monoclonal antibodies to deliver one of ImmunoGen's proprietary cancer cell-killing agents specifically to tumor cells. There are now numerous TAP compounds in clinical development with a wealth of clinical data reported. ImmunoGen's collaborative partners include Amgen, Bayer HealthCare, Biotest, Lilly, Novartis, Roche and Sanofi. The most advanced compound using ImmunoGen's TAP technology, trastuzumab emtansine (T-DM1), is in Phase III testing through the Company's collaboration with Genentech, a member of the Roche Group. More information about ImmunoGen can be found at

This press release includes forward-looking statements. For these statements, ImmunoGen claims the protection of the safe harbor for forward-looking statements provided by the Private Securities Litigation Reform Act of 1995. It should be noted that there are risks and uncertainties related to the development of novel anticancer products, including trastuzumab emtansine, including risks related to clinical studies and regulatory submissions, their timings and results. A review of these risks can be found in ImmunoGen's Annual Report on Form 10-K for the fiscal year ended June 30, 2011 and other reports filed with the Securities and Exchange Commission.

Tykerb® is a registered trademark of GlaxoSmithKline plc.
Xeloda® is a registered trademark of Roche.
Herceptin® is a registered trademark of Genentech, a member of the Roche Group.

For Investors:
ImmunoGen, Inc.
Carol Hausner, 781-895-0600
Executive Director, Investor Relations and Corporate Communications
For Media:
The Yates Network
Barbara Yates, 781-258-6153

Source: ImmunoGen, Inc.

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